Circulating Tumor Cells Adhesion: Application in Biosensors

Overview

Journal Biosensors (Basel)

Specialty Biotechnology

Date 2023 Sep 27

PMID 37754116

Authors

Eduarda B Paglia

Estela K K Baldin

Gabriela P Freitas

Thalyta S A Santiago

Joao B M R Neto

Jorge V L Silva

Hernandes F Carvalho

Marisa M Beppu

Affiliations

Soon will be listed here.

Abstract

The early and non-invasive diagnosis of tumor diseases has been widely investigated by the scientific community focusing on the development of sensors/biomarkers that act as a way of recognizing the adhesion of circulating tumor cells (CTCs). As a challenge in this area, strategies for CTCs capture and enrichment currently require improvements in the sensors/biomarker's selectivity. This can be achieved by understanding the biological recognition factors for different cancer cell lines and also by understanding the interaction between surface parameters and the affinity between macromolecules and the cell surface. To overcome some of these concerns, electrochemical sensors have been used as precise, fast-response, and low-cost transduction platforms for application in cytosensors. Additionally, distinct materials, geometries, and technologies have been investigated to improve the sensitivity and specificity properties of the support electrode that will transform biochemical events into electrical signals. This review identifies novel approaches regarding the application of different specific biomarkers (CD44, Integrins, and EpCAm) for capturing CTCs. These biomarkers can be applied in electrochemical biosensors as a cytodetection strategy for diagnosis of cancerous diseases.

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