Considerations for Intensity Modulated Total Body or Total Marrow and Lymphoid Irradiation

Overview

Journal Clin Transl Radiat Oncol

Specialty Oncology

Date 2023 Sep 27

PMID 37753462

Authors

David Parsons

Tze Yee Lim

Jose R Teruel

Paulina Galavis

Stefano Agostinelli

Jieming Liang

Pietro Mancosu

Amanda Cherpak

Dennis N Stanley

Kang-Hyun Ahn

Bingqi Guo

Yesenia Gonzalez

Jay Burmeister

Jeffrey Y C Wong

Xuejun Gu

Grace Gwe-Ya Kim

Affiliations

Soon will be listed here.

Abstract

We compiled a sampling of the treatment techniques of intensity-modulated total body irradiation, total marrow irradiation and total marrow and lymphoid irradiation utilized by several centers across North America and Europe. This manuscript does not serve as a consensus guideline, but rather is meant to serve as a convenient reference for centers that are considering starting an intensity-modulated program.

References

Reilly M, Dandapani S, Kumar K, Constine L, Fogh S, Roberts K . ACR-ARS Practice Parameter for the Performance of Total Body Irradiation. Am J Clin Oncol. 2023; 46(5):185-192. DOI: 10.1097/COC.0000000000000997. View

Keit E, Liveringhouse C, Figura N, Weygand J, Sandoval M, Garcia G . Feasibility and Toxicity of Full-Body Volumetric Modulated Arc Therapy Technique for High-Dose Total Body Irradiation. Technol Cancer Res Treat. 2023; 22:15330338231180779. PMC: 10272663. DOI: 10.1177/15330338231180779. View

Teruel J, Taneja S, Galavis P, Osterman K, McCarthy A, Malin M . Automatic treatment planning for VMAT-based total body irradiation using Eclipse scripting. J Appl Clin Med Phys. 2021; 22(3):119-130. PMC: 7984467. DOI: 10.1002/acm2.13189. View

Kim D, Kim I, Yoon S, Kang H, Shin H, Kang H . Effect of dose rate on pulmonary toxicity in patients with hematolymphoid malignancies undergoing total body irradiation. Radiat Oncol. 2018; 13(1):180. PMC: 6145366. DOI: 10.1186/s13014-018-1116-9. View

Guo B, Sheen C, Murphy E, Magnelli A, Lu L, Cho Y . Image-guided volumetric-modulated arc therapy of total body irradiation: An efficient workflow from simulation to delivery. J Appl Clin Med Phys. 2021; 22(10):169-177. PMC: 8504588. DOI: 10.1002/acm2.13412. View

Kim T, Rybka W, Lehnert S, Podgorsak E, Freeman C . Interstitial pneumonitis following total body irradiation for bone marrow transplantation using two different dose rates. Int J Radiat Oncol Biol Phys. 1985; 11(7):1285-91. DOI: 10.1016/0360-3016(85)90243-3. View

Moliner G, Izar F, Ferrand R, Bardies M, Ken S, Simon L . Virtual bolus for total body irradiation treated with helical tomotherapy. J Appl Clin Med Phys. 2015; 16(6):164–176. PMC: 5691005. DOI: 10.1120/jacmp.v16i6.5580. View

Salz H, Bohrisch B, Howitz S, Banz N, Weibert K, Wiezorek T . Intensity-modulated Total Body Irradiation (TBI) with TomoDirect™. Radiat Oncol. 2015; 10:58. PMC: 4353674. DOI: 10.1186/s13014-015-0362-3. View

Sarina B, Mancosu P, Navarria P, Bramanti S, Mariotti J, De Philippis C . Nonmyeloablative Conditioning Regimen Including Low-Dose Total Marrow/Lymphoid Irradiation Before Haploidentical Transplantation with Post-Transplantation Cyclophosphamide in Patients with Advanced Lymphoproliferative Diseases. Transplant Cell Ther. 2021; 27(6):492.e1-492.e6. DOI: 10.1016/j.jtct.2021.03.013. View

10.

Mancosu P, Navarria P, Paul Muren L, Castagna L, Reggiori G, Clerici E . Development of an Immobilization Device for Total Marrow Irradiation. Pract Radiat Oncol. 2020; 11(1):e98-e105. DOI: 10.1016/j.prro.2020.02.012. View

11.

Abugideiri M, Nanda R, Butker C, Zhang C, Kim S, Chiang K . Factors Influencing Pulmonary Toxicity in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation in the Setting of Total Body Irradiation-Based Myeloablative Conditioning. Int J Radiat Oncol Biol Phys. 2016; 94(2):349-59. DOI: 10.1016/j.ijrobp.2015.10.054. View

12.

Kasai Y, Fukuyama Y, Terashima H, Nakamura K, Sasaki T . Dose evaluation indices for total body irradiation using TomoDirect with different numbers of ports: A comparison with the TomoHelical method. J Appl Clin Med Phys. 2019; 20(2):129-135. PMC: 6370990. DOI: 10.1002/acm2.12540. View

13.

Ahn K, Rondelli D, Koshy M, Partouche J, Hasan Y, Liu H . Knowledge-based planning for multi-isocenter VMAT total marrow irradiation. Front Oncol. 2022; 12:942685. PMC: 9577613. DOI: 10.3389/fonc.2022.942685. View

14.

Surucu M, Yeginer M, Kavak G, Fan J, Radosevich J, Aydogan B . Verification of dose distribution for volumetric modulated arc therapy total marrow irradiation in a humanlike phantom. Med Phys. 2012; 39(1):281-8. DOI: 10.1118/1.3668055. View

15.

Ozsahin M, Belkacemi Y, Pene F, Laporte J, Rio B, Leblond V . Interstitial pneumonitis following autologous bone-marrow transplantation conditioned with cyclophosphamide and total-body irradiation. Int J Radiat Oncol Biol Phys. 1996; 34(1):71-7. DOI: 10.1016/0360-3016(95)02063-2. View

16.

Lambri N, Dei D, Hernandez V, Castiglioni I, Clerici E, Crespi L . Automatic planning of the lower extremities for total marrow irradiation using volumetric modulated arc therapy. Strahlenther Onkol. 2022; 199(4):412-419. PMC: 10033624. DOI: 10.1007/s00066-022-02014-0. View

17.

Ladbury C, Hao C, Yang D, Hui S, Han C, Liu A . Long-term follow up of patients with hematological malignancies treated with total body irradiation using intensity modulated radiation therapy. Front Oncol. 2022; 12:1044539. PMC: 9755353. DOI: 10.3389/fonc.2022.1044539. View

18.

Cherpak A, Monajemi T, Chytyk-Praznik K, Mulroy L . Energy-dependent OAR sparing and dose conformity for total marrow irradiation of obese patients. J Appl Clin Med Phys. 2018; 19(5):532-538. PMC: 6123143. DOI: 10.1002/acm2.12413. View

19.

Mancosu P, Navarria P, Castagna L, Reggiori G, Sarina B, Tomatis S . Interplay effects between dose distribution quality and positioning accuracy in total marrow irradiation with volumetric modulated arc therapy. Med Phys. 2013; 40(11):111713. DOI: 10.1118/1.4823767. View

20.

Aydogan B, Yeginer M, Kavak G, Fan J, Radosevich J, Gwe-Ya K . Total marrow irradiation with RapidArc volumetric arc therapy. Int J Radiat Oncol Biol Phys. 2011; 81(2):592-9. DOI: 10.1016/j.ijrobp.2010.11.035. View