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Breaching the Blood-brain Barrier: AAV Triggers Dose-dependent Toxicity in the Brain

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Publisher Cell Press
Date 2023 Sep 27
PMID 37753219
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References
1.
Guo Y, Chen J, Ji W, Xu L, Xie Y, He S . High-titer AAV disrupts cerebrovascular integrity and induces lymphocyte infiltration in adult mouse brain. Mol Ther Methods Clin Dev. 2023; 31:101102. PMC: 10518493. DOI: 10.1016/j.omtm.2023.08.021. View

2.
Hordeaux J, Buza E, Jeffrey B, Song C, Jahan T, Yuan Y . MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primates. Sci Transl Med. 2020; 12(569). DOI: 10.1126/scitranslmed.aba9188. View

3.
Samaranch L, San Sebastian W, Kells A, Salegio E, Heller G, Bringas J . AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction. Mol Ther. 2014; 22(2):329-337. PMC: 3918916. DOI: 10.1038/mt.2013.266. View

4.
Klein R, Dayton R, Leidenheimer N, Jansen K, Golde T, Zweig R . Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins. Mol Ther. 2005; 13(3):517-27. PMC: 2987642. DOI: 10.1016/j.ymthe.2005.10.008. View

5.
Hordeaux J, Buza E, Dyer C, Goode T, Mitchell T, Richman L . Adeno-Associated Virus-Induced Dorsal Root Ganglion Pathology. Hum Gene Ther. 2020; 31(15-16):808-818. DOI: 10.1089/hum.2020.167. View