Investigation of Microbial Coinfection in 453 Septic COVID-19 Patients Admitted to Hospital; a Retrospective Study

Overview

Journal Future Sci OA

Specialty Biotechnology

Date 2023 Sep 27

PMID 37752919

Authors

Armin Khavandegar

Zeinab Siami

Sogand Goudarzi

Aziz Rasooli

Yeganeh Ettehad

Affiliations

Soon will be listed here.

Abstract

Aim: We evaluated the rate of COVID-19 microbial coinfection in an Iranian population.

Methods: In this single-center, retrospective observational study, we evaluated 453 septic COVID-19 patients for possible coinfection in an Iranian hospital.

Results: Overall, 211 (46.57%) cases died due to COVID-19 complications. Positive respiratory secretion and blood cultures were reported in 99 (21.9%) and 19 (4.2%) cases. species were the most commonly isolated microorganisms in respiratory (n = 50, 50.5%) and blood (n = 10, 52.6%) specimens. After adjustment for underlying disorders, positive respiratory microbial cultures significantly increase the odds of developing death, intubation, and ICU admission and negatively impact healthy discharge (P < 0.05).

Conclusion: Coinfections with bacteria and fungi independently contribute to poor outcomes in septic COVID-19 patients.

Citing Articles

Impact of healthcare-associated infections on in-hospital outcomes during the COVID-19 era: a multicenter comparative study of 20,942 isolated microorganisms from ICU patients.

Khavandegar A, Siami Z, Rasouli A, Nazemi P, Gull A Front Public Health. 2025; 13:1475221.

PMID: 39991697 PMC: 11842308. DOI: 10.3389/fpubh.2025.1475221.

Candidemia Following Severe COVID-19 in Hospitalised and Critical Ill Patients: A Systematic Review and Meta-Analysis.

Srisurapanont K, Lerttiendamrong B, Meejun T, Thanakitcharu J, Manothummetha K, Thongkam A Mycoses. 2024; 67(10):e13798.

PMID: 39379339 PMC: 11607781. DOI: 10.1111/myc.13798.

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