Expert Discussion on Challenges in C3G Diagnosis: A Podcast Article on Best Practices in Kidney Biopsies

Overview

Journal Adv Ther

Date 2023 Sep 26

PMID 37751024

Authors

Richard A Lafayette

Vivek Charu

Affiliations

Soon will be listed here.

Abstract

Complement 3 glomerulopathy (C3G) is an ultra-rare, progressive kidney disease resulting from dysregulation of the alternative complement pathway. Clinical presentation of C3G is heterogeneous and definitive diagnosis relies on kidney biopsy and immunofluorescence staining. The term C3G encompasses two subgroups, dense deposit disease and C3 glomerulonephritis, distinguished via electron microscopy. In this podcast article, the authors discuss the challenges associated with C3G diagnosis and the central role of kidney biopsy. Using an illustrative case study, key histological observations are described, and best practices are discussed from the perspectives of a nephrologist and a nephropathologist. Podcast Audio (MP4 141866 KB).

Citing Articles

Challenges in the Diagnosis and Management of Immune Complex-Mediated Membranoproliferative Glomerulonephritis and Complement 3 Glomerulopathy.

Bomback A, Charu V, Fakhouri F Kidney Int Rep. 2025; 10(1):17-28.

PMID: 39810761 PMC: 11725974. DOI: 10.1016/j.ekir.2024.09.017.

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