Supramolecular Assembly of Pyrene-DNA Conjugates: Influence of Pyrene Substitution Pattern and Implications for Artificial LHCs

Overview

Journal Org Biomol Chem

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2023 Sep 26

PMID 37750811

Authors

Jan Thiede

Simon Rothenbuhler

Ioan Iacovache

Simon M Langenegger

Benoit Zuber

Robert Haner

Affiliations

Soon will be listed here.

Abstract

The supramolecular self-assembly of pyrene-DNA conjugates into nanostructures is presented. DNA functionalized with different types of pyrene isomers at the 3'-end self-assemble into nano-objects. The shape of the nanostructures is influenced by the type of pyrene isomer appended to the DNA. Multilamellar vesicles are observed with the 1,6- and 1,8-isomers, whereas conjugates of the 2,7-isomer exclusively assemble into spherical nanoparticles. Self-assembled nano-spheres obtained with the 2,7-dialkynyl pyrene isomer were used for the construction of an artificial light-harvesting complex (LHC) in combination with Cy3 as the energy acceptor.

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