Cross-talk Between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells

Overview

Journal Cancer Res

Specialty Oncology

Date 2023 Sep 25

PMID 37747775

Authors

Jinlong Yin

Yoona Seo

Jiho Rhim

Xiong Jin

Tae Hoon Kim

Sung Soo Kim

Jun-Hee Hong

Ho-Shin Gwak

Heon Yoo

Jong Bae Park

Jong Heon Kim

Affiliations

Soon will be listed here.

Abstract

Significance: A positive feedback loop comprising PARN and EGFR-STAT3 signaling supports self-renewal and proliferation of glioblastoma stem cells to drive tumor progression and can be targeted in glioblastoma therapeutics.

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