Association of Serum Complement C3 Levels with Severity and Mortality in COVID 19

Overview

Journal Indian J Clin Biochem

Specialty Biochemistry

Date 2023 Sep 25

PMID 37746543

Authors

Sojit Tomo

Pvsn Kiran Kumar

Dharamveer Yadav

Shrimanjunath Sankanagoudar

Jayakaran Charan

Abhishek Purohit

Vijaya Lakshmi Nag

Pradeep Kumar Bhatia

Kuldeep Singh

Naveen Dutt

Mahendra Kumar Garg

Sanjeev Misra

Praveen Sharma

Purvi Purohit

Affiliations

Soon will be listed here.

Abstract

Supplementary Information: The online version contains supplementary material available at 10.1007/s12291-023-01148-x.

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References

Posch W, Vosper J, Noureen A, Zaderer V, Witting C, Bertacchi G . C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2-infected primary human airway epithelia. J Allergy Clin Immunol. 2021; 147(6):2083-2097.e6. PMC: 8056780. DOI: 10.1016/j.jaci.2021.03.038. View

Mastaglio S, Ruggeri A, Risitano A, Angelillo P, Yancopoulou D, Mastellos D . The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clin Immunol. 2020; 215:108450. PMC: 7189192. DOI: 10.1016/j.clim.2020.108450. View

Zhang Z, Li X, Zhang W, Shi Z, Zheng Z, Wang T . Clinical Features and Treatment of 2019-nCov Pneumonia Patients in Wuhan: Report of A Couple Cases. Virol Sin. 2020; 35(3):330-336. PMC: 7091133. DOI: 10.1007/s12250-020-00203-8. View

Fang S, Wang H, Lu L, Jia Y, Xia Z . Decreased complement C3 levels are associated with poor prognosis in patients with COVID-19: A retrospective cohort study. Int Immunopharmacol. 2020; 89(Pt A):107070. PMC: 7534659. DOI: 10.1016/j.intimp.2020.107070. View

Lappegard K, Fung M, Bergseth G, Riesenfeld J, Lambris J, Videm V . Effect of complement inhibition and heparin coating on artificial surface-induced leukocyte and platelet activation. Ann Thorac Surg. 2004; 77(3):932-41. DOI: 10.1016/S0003-4975(03)01519-4. View

Macor P, Durigutto P, Mangogna A, Bussani R, De Maso L, DErrico S . Multiple-Organ Complement Deposition on Vascular Endothelium in COVID-19 Patients. Biomedicines. 2021; 9(8). PMC: 8394811. DOI: 10.3390/biomedicines9081003. View

Campbell C, Kahwash R . Will Complement Inhibition Be the New Target in Treating COVID-19-Related Systemic Thrombosis?. Circulation. 2020; 141(22):1739-1741. DOI: 10.1161/CIRCULATIONAHA.120.047419. View

Barkoff C, Mousa S . Pharmacotherapy in COVID 19: Potential Impact of Targeting the Complement System. Biomedicines. 2020; 9(1). PMC: 7823480. DOI: 10.3390/biomedicines9010011. View

Fletcher-Sandersjoo A, Bellander B . Is COVID-19 associated thrombosis caused by overactivation of the complement cascade? A literature review. Thromb Res. 2020; 194:36-41. PMC: 7301826. DOI: 10.1016/j.thromres.2020.06.027. View

10.

Zinellu A, Mangoni A . Serum Complement C3 and C4 and COVID-19 Severity and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression. Front Immunol. 2021; 12:696085. PMC: 8215447. DOI: 10.3389/fimmu.2021.696085. View

11.

Java A, Apicelli A, Liszewski M, Coler-Reilly A, Atkinson J, Kim A . The complement system in COVID-19: friend and foe?. JCI Insight. 2020; 5(15). PMC: 7455060. DOI: 10.1172/jci.insight.140711. View

12.

Tomo S, Karli S, Dharmalingam K, Yadav D, Sharma P . The Clinical Laboratory: A Key Player in Diagnosis and Management of COVID-19. EJIFCC. 2020; 31(4):326-346. PMC: 7745302. View

13.

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z . Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; 395(10229):1054-1062. PMC: 7270627. DOI: 10.1016/S0140-6736(20)30566-3. View

14.

Jiang H, Chen Q, Zheng S, Guo C, Luo J, Wang H . Association of Complement C3 with Clinical Deterioration Among Hospitalized Patients with COVID-19. Int J Gen Med. 2022; 15:849-857. PMC: 8801723. DOI: 10.2147/IJGM.S348519. View

15.

Li X, Zhong X, Wang Y, Zeng X, Luo T, Liu Q . Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis. PLoS One. 2021; 16(5):e0250602. PMC: 8092779. DOI: 10.1371/journal.pone.0250602. View

16.

Varela J, Tomlinson S . Complement: an overview for the clinician. Hematol Oncol Clin North Am. 2015; 29(3):409-27. PMC: 4456616. DOI: 10.1016/j.hoc.2015.02.001. View

17.

Chang D, Lin M, Wei L, Xie L, Zhu G, Dela Cruz C . Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China. JAMA. 2020; 323(11):1092-1093. PMC: 7042871. DOI: 10.1001/jama.2020.1623. View

18.

Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y . Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis. 2020; 71(15):762-768. PMC: 7108125. DOI: 10.1093/cid/ciaa248. View

19.

Cheng W, Hornung R, Xu K, Yang C, Li J . Complement C3 identified as a unique risk factor for disease severity among young COVID-19 patients in Wuhan, China. Sci Rep. 2021; 11(1):7857. PMC: 8042103. DOI: 10.1038/s41598-021-82810-3. View

20.

Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z . D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. J Thromb Haemost. 2020; 18(6):1324-1329. PMC: 7264730. DOI: 10.1111/jth.14859. View