Case-Control Trials on Risk Factors for Pancreatic Cancer: A Systematic Review and Meta-Analysis

Overview

Journal Iran J Public Health

Date 2023 Sep 25

PMID 37744539

Authors

Yan Yang

Jianwei Shi

Jiaoling Huang

Mingwang Cheng

Shasha Geng

Wenya Yu

Ning Chen

Chen Chen

Zhaoxin Wang

Affiliations

Soon will be listed here.

Abstract

Background: The single risk factors of pancreatic cancer (PC) has been extensively studied. We aimed to synthesize results from such studies to identify and estimate multiple independent risk factors of PC.

Methods: Articles published up to Feb 28, 2020 in English or Chinese reporting risk factors of PC were reviewed. The fixed-effects model with 95% confidence interval (CI) were used to calculate the pooled Odds Ratio (OR). Data were analyzed using RevMan 5.3.

Results: PC was significantly associated with smoking (: 1.76, 95% : 1.61-1.92, < 0.00001, = 6%), diabetes (: 2.69, 95% : 2.52-2.88, < 0.00001, = 0%), family history of PC (: 2.58, 95% : 2.13-3.11, < 0.00001, = 0%), and chronic pancreatitis (: 5.84, 95% : 3.63-9.41, < 0.00001, = 0%).

Conclusion: Smoking, diabetes, family history of PC, and chronic pancreatitis were independent risk factors for PC. These independent risk factors have an important role in identifying high-risk groups, which is of great significance to reduce the incidence of PC and improve the quality of life and prognosis of patients.

Citing Articles

Molecular Targets for the Diagnosis and Treatment of Pancreatic Cancer.

Pergolizzi R, Brower S Int J Mol Sci. 2024; 25(19).

PMID: 39409171 PMC: 11476914. DOI: 10.3390/ijms251910843.

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