Preoperative Lymphocyte Count, Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratio Predict the Recurrence with Progression and Cancerization in Vocal Fold Lesions-retrospective Study

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2023 Sep 25

PMID 37744219

Authors

Anna Rzepakowska

Wioletta Pietruszewska

Michal Zurek

Maria Molga-Magusiak

Michal Leszczynski

Kazimierz Niemczyk

Affiliations

Soon will be listed here.

Abstract

Backgrounds: This study explored the contribution of peripheral blood markers in diagnosis and prognosis estimation of different stages of laryngeal dysplasia and early glottic cancer.

Methods: Retrospective analysis of clinical, histopathological and laboratory data of 220 patients including hemoglobin, neutrophil, lymphocyte, monocyte and platelet counts, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR).

Results: The mean hemoglobin level and platelets count showed differences between histopathological stages of lesions ( = 0.041 and 0.046, respectively). In patients with recurrent lesions mean level of lymphocyte count, NLR and PLR were significant in assessing progression and cancerization ( = 0.005, 0.028 and 0.023, respectively). The univariate analysis recognized level of PLR ≥ 141.74 as significant risk factor of the recurrence of vocal fold hypertrophic lesions (OR = 1.963).

Conclusions: The levels of blood cells and their ratios seem to be effective in predicting the recurrence of lesion and even more their potential role in indicating malignant progression.

References

Kum R, Ozcan M, Baklaci D, Kum N, Yilmaz Y, Gungor V . Elevated neutrophil-to-lymphocyte ratio in squamous cell carcinoma of larynx compared to benign and precancerous laryngeal lesions. Asian Pac J Cancer Prev. 2014; 15(17):7351-5. DOI: 10.7314/apjcp.2014.15.17.7351. View

Malzahn K, Dreyer T, Glanz H, Arens C . Autofluorescence endoscopy in the diagnosis of early laryngeal cancer and its precursor lesions. Laryngoscope. 2002; 112(3):488-93. DOI: 10.1097/00005537-200203000-00015. View

Shen M, Hu P, Donskov F, Wang G, Liu Q, Du J . Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis. PLoS One. 2014; 9(6):e98259. PMC: 4048155. DOI: 10.1371/journal.pone.0098259. View

Miyamoto R, Inagawa S, Sano N, Tadano S, Adachi S, Yamamoto M . The neutrophil-to-lymphocyte ratio (NLR) predicts short-term and long-term outcomes in gastric cancer patients. Eur J Surg Oncol. 2018; 44(5):607-612. DOI: 10.1016/j.ejso.2018.02.003. View

Galizia G, Lieto E, Zamboli A, De Vita F, Castellano P, Romano C . Neutrophil to lymphocyte ratio is a strong predictor of tumor recurrence in early colon cancers: A propensity score-matched analysis. Surgery. 2015; 158(1):112-20. DOI: 10.1016/j.surg.2015.02.006. View

Coussens L, Werb Z . Inflammation and cancer. Nature. 2002; 420(6917):860-7. PMC: 2803035. DOI: 10.1038/nature01322. View

Oberg H, Wesch D, Kalyan S, Kabelitz D . Regulatory Interactions Between Neutrophils, Tumor Cells and T Cells. Front Immunol. 2019; 10:1690. PMC: 6657370. DOI: 10.3389/fimmu.2019.01690. View

Fang Y, Chen M, Yang Y, Chen J, Cheng L, He P . The Variation of Peripheral Inflammatory Markers in Vocal Leukoplakia before and after Recurrence and Canceration. Dis Markers. 2020; 2020:7241785. PMC: 7422067. DOI: 10.1155/2020/7241785. View

Bae J, Lee C, Han S, Park S, Lee Y, Lee I . Differences in the prognostic impact of post-operative systemic inflammation and infection in colorectal cancer patients: Using white blood cell counts and procalcitonin levels. Surg Oncol. 2020; 35:374-381. DOI: 10.1016/j.suronc.2020.09.017. View

10.

Tsai Y, Wang C, Chen C, Lin L, Hwang T, Lu L . Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer. Head Neck. 2013; 36(7):947-53. DOI: 10.1002/hed.23400. View

11.

Gu X, Gao X, Li X, Qi X, Ma M, Qin S . Prognostic significance of neutrophil-to-lymphocyte ratio in prostate cancer: evidence from 16,266 patients. Sci Rep. 2016; 6:22089. PMC: 4766531. DOI: 10.1038/srep22089. View

12.

Templeton A, McNamara M, Seruga B, Vera-Badillo F, Aneja P, Ocana A . Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst. 2014; 106(6):dju124. DOI: 10.1093/jnci/dju124. View

13.

Gaykalova D, Mambo E, Choudhary A, Houghton J, Buddavarapu K, Sanford T . Novel insight into mutational landscape of head and neck squamous cell carcinoma. PLoS One. 2014; 9(3):e93102. PMC: 3965530. DOI: 10.1371/journal.pone.0093102. View

14.

Yodying H, Matsuda A, Miyashita M, Matsumoto S, Sakurazawa N, Yamada M . Prognostic Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Oncologic Outcomes of Esophageal Cancer: A Systematic Review and Meta-analysis. Ann Surg Oncol. 2015; 23(2):646-54. DOI: 10.1245/s10434-015-4869-5. View

15.

Chen L, Zeng H, Yang J, Lu Y, Zhang D, Wang J . Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma. BMC Cancer. 2018; 18(1):816. PMC: 6090788. DOI: 10.1186/s12885-018-4730-x. View

16.

Sheng X, Zhang H, Ge P, Chen L, Zhang S . A Retrospective Study of The Prognostic Significance of Preoperative Plasma Fibrinogen, Mean Platelet Volume, and the Neutrophil-to-Lymphocyte Ratio in Patients with Laryngeal Squamous Cell Carcinoma. Med Sci Monit. 2019; 25:4527-4534. PMC: 6597139. DOI: 10.12659/MSM.914426. View

17.

Ozdemir Y, Akin M, Sucullu I, Balta A, Yucel E . Pretreatment neutrophil/lymphocyte ratio as a prognostic aid in colorectal cancer. Asian Pac J Cancer Prev. 2014; 15(6):2647-50. DOI: 10.7314/apjcp.2014.15.6.2647. View

18.

Racz J, Cleghorn M, Jimenez M, Atenafu E, Jackson T, Okrainec A . Predictive Ability of Blood Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Gastrointestinal Stromal Tumors. Ann Surg Oncol. 2014; 22(7):2343-50. DOI: 10.1245/s10434-014-4265-6. View

19.

Song S, Chen H, Dong W, Zhou H . The prognostic value of preoperative derived neutrophil-to-lymphocyte ratio in patients undergoing total laryngectomy with laryngeal carcinoma. Acta Otolaryngol. 2019; 139(3):294-298. DOI: 10.1080/00016489.2019.1566780. View

20.

Miyaguchi M, Olofsson J, Hellquist H . Expression of epidermal growth factor receptor in laryngeal dysplasia and carcinoma. Acta Otolaryngol. 1990; 110(3-4):309-13. DOI: 10.3109/00016489009122553. View