Polymicrogyria in a Patient After Twin-twin Transfusion Syndrome

Overview

Journal BMJ Case Rep

Specialty General Medicine

Date 2023 Sep 22

PMID 37739446

Authors

Eva Karner

Gregor J Kasprian

Alex Farr

Elisabeth Krampl-Bettelheim

Affiliations

Soon will be listed here.

Abstract

This case report presents a patient with a monochorionic twin pregnancy, development of twin-twin transfusion-syndrome (TTTS) and polymicrogyria (PMG) of one fetus. Due to TTTS grade 3, fetoscopic laser ablation was performed at gestational week 16+1. Sonographic follow-up showed a cortical malformation of the right parietal lobe in the former donor, which was identified as PMG by MRI scans. We describe the course of the pregnancy, as well as the clinical, especially neurological, development of the child over 3 years. This case report documents the power of neuroplasticity, leading to comparably good neurological outcome in an extensive, likely acquired cortical malformation. Further, it emphasises the importance of a thorough prenatal imaging characterisation of malformations of cortical development for optimal prenatal counselling of these cases.

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