Microbiological Characteristics and Risk Factors Involved in Progression from Fungal Keratitis with Hypopyon to Keratitis-Related Endophthalmitis

Overview

Journal Mycopathologia

Specialties Microbiology
Pharmacology

Date 2023 Sep 22

PMID 37737909

Authors

Yu Sun

Fanxing Zeng

Jingjing Zhang

Xiaolin Qi

Xiuhai Lu

Na Ning

Suxia Li

Ting Zhang

Gongqiang Yuan

Weiyun Shi

Hua Gao

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate the differences in microbiological characteristics, risk factors, drug resistance, and visual outcomes in three infections: fungal keratitis with hypopyon (FKH), keratitis-related fungal endophthalmitis (FKE), and fungal endophthalmitis without keratitis (FE).

Methods: An analytical cross-sectional study.

Results: In total, 14.57% of eyes with FKH progressed to endophthalmitis. Hypopyon, pre-existence of lens problems, topical steroid use and sever keratitis were significantly associated with the development of FKE. The risk factors of the FKH and FE group were mainly plant trauma and open globe trauma, respectively. Keratitis-related endophthalmitis (FKE) showed a significantly higher resistance than the other two groups. The FKH group had the best final visual acuity, while the FKE group had the worst.

Conclusion: Hypopyon height, pre-existing lens problems, topical steroid use and sever keratitis are risk factors for progression to endophthalmitis in eyes with fungal keratitis, and its progression is not affected by a single fungus. The antifungal drugs resistance in patients with endophthalmitis related to keratitis was significantly higher than that associated with other reasons. Timely diagnosis and risk factor assessment are essential for ensuring early treatment of FKE.

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