Outbreak of Sexually Transmitted Nongroupable Neisseria Meningitidis-Associated Urethritis, Vietnam

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2023 Sep 22

PMID 37735771

Authors

Hao Trong Nguyen

Thanh V Phan

Hau Phuc Tran

Thao Thi Phuong Vu

Nhi Thi Uyen Pham

Tho Thi Thanh Nguyen

Ha Manh Bui

Bao Hac Duong

Thu Nguyen Anh Luu

Nguyen Nhat Pham

Phuc Duy Nguyen

Tu Ngoc Le

Thu Quang Le

Dai Thi Trang Vo

Lan Trong Phan

Nghia Van Khuu

Quang Duy Pham

Thuong Vu Nguyen

Affiliations

Soon will be listed here.

Abstract

We report on an outbreak of nongroupable Neisseria meningitidis-associated urethritis, primarily among men who have sex with men in southern Vietnam. Nearly 50% of N. meningitidis isolates were resistant to ciprofloxacin. This emerging pathogen should be considered in the differential diagnosis and management of urethritis.

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References

Taha M, Vazquez J, Hong E, Bennett D, Bertrand S, Bukovski S . Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis. Antimicrob Agents Chemother. 2007; 51(8):2784-92. PMC: 1932518. DOI: 10.1128/AAC.00412-07. View

Hong E, Thulin Hedberg S, Abad R, Fazio C, Enriquez R, Deghmane A . Target gene sequencing to define the susceptibility of Neisseria meningitidis to ciprofloxacin. Antimicrob Agents Chemother. 2013; 57(4):1961-4. PMC: 3623314. DOI: 10.1128/AAC.02184-12. View

Retchless A, Kretz C, Chang H, Bazan J, Abrams A, Norris Turner A . Expansion of a urethritis-associated Neisseria meningitidis clade in the United States with concurrent acquisition of N. gonorrhoeae alleles. BMC Genomics. 2018; 19(1):176. PMC: 5834837. DOI: 10.1186/s12864-018-4560-x. View

Brooks A, Lucidarme J, Campbell H, Campbell L, Fifer H, Gray S . Detection of the United States urethritis clade in the United Kingdom, August and December 2019 - emergence of multiple antibiotic resistance calls for vigilance. Euro Surveill. 2020; 25(15). PMC: 7175650. DOI: 10.2807/1560-7917.ES.2020.25.15.2000375. View

Unemo M, Shafer W . Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future. Clin Microbiol Rev. 2014; 27(3):587-613. PMC: 4135894. DOI: 10.1128/CMR.00010-14. View

Bazan J, Peterson A, Kirkcaldy R, Briere E, Maierhofer C, Norris Turner A . Notes from the Field: Increase in Neisseria meningitidis-Associated Urethritis Among Men at Two Sentinel Clinics - Columbus, Ohio, and Oakland County, Michigan, 2015. MMWR Morb Mortal Wkly Rep. 2016; 65(21):550-2. PMC: 5390329. DOI: 10.15585/mmwr.mm6521a5. View

Maini M, French P, Prince M, Bingham J . Urethritis due to Neisseria meningitidis in a London genitourinary medicine clinic population. Int J STD AIDS. 1992; 3(6):423-5. DOI: 10.1177/095646249200300604. View

Adamson P, Le H, Le H, Le G, Nguyen T, Klausner J . Trends in antimicrobial resistance in Neisseria gonorrhoeae in Hanoi, Vietnam, 2017-2019. BMC Infect Dis. 2020; 20(1):809. PMC: 7643326. DOI: 10.1186/s12879-020-05532-3. View

Nguyen T, Do T, Nguyen H, Nguyen C, Meyer J, Godman B . A National Survey of Dispensing Practice and Customer Knowledge on Antibiotic Use in Vietnam and the Implications. Antibiotics (Basel). 2022; 11(8). PMC: 9405246. DOI: 10.3390/antibiotics11081091. View

10.

Hayakawa K, Itoda I, Shimuta K, Takahashi H, Ohnishi M . Urethritis caused by novel Neisseria meningitidis serogroup W in man who has sex with men, Japan. Emerg Infect Dis. 2014; 20(9):1585-7. PMC: 4178410. DOI: 10.3201/eid2009.140349. View

11.

Givan K, Keyl A . The isolation of Neisseria species from unusual sites. Can Med Assoc J. 1974; 111(10):1077-9. PMC: 1955836. View

12.

Lan P, Golparian D, Ringlander J, Hung L, Thuong N, Unemo M . Genomic analysis and antimicrobial resistance of Neisseria gonorrhoeae isolates from Vietnam in 2011 and 2015-16. J Antimicrob Chemother. 2020; 75(6):1432-1438. PMC: 7382555. DOI: 10.1093/jac/dkaa040. View