Renal Involvement in Systemic Lupus Erythematosus: Additional Histopathological Lesions

Overview

Journal Arch Med Sci

Specialty General Medicine

Date 2023 Sep 21

PMID 37732045

Authors

Monique Pereira Rego Muniz

Laise Pereira Arcoverde Fechine Brito

Pedro Henrique Cavalcante Vale

Felipe Leite Guedes

Thina Klicia Mendonca Oliveira

Dyego Jose de Araujo Brito

Natalino Salgado Filho

Marcio Dantas

Gyl Eanes Barros Silva

Affiliations

Soon will be listed here.

Abstract

A common criticism of the classification of lupus nephritis is the relative scarcity of information regarding tubular, interstitial, and vascular changes compared to the available information regarding glomerular changes, even though their potential for independent progression is known. This study reviewed the importance of less explored lesions by the current and widely used 2003 classification of lupus nephritis of the International Society of Nephrology/Renal Pathology Society (ISN/RPS), with emphasis on the tubulointerstitial, podocyte, and vascular lesions, increasingly recognised as being important in the pathogenesis and prognosis of the disease. Recognition of these lesions can help with therapeutic decision-making, thereby allowing better results for patients with systemic lupus erythematosus.

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References

Amann K . Do ANCAs make the difference in lupus nephritis?. Kidney Int. 2017; 92(5):1048-1050. DOI: 10.1016/j.kint.2017.07.011. View

Wilhelmus S, Alpers C, Cook H, Ferrario F, Fogo A, Haas M . The Revisited Classification of GN in SLE at 10 Years: Time to Re-Evaluate Histopathologic Lesions. J Am Soc Nephrol. 2015; 26(12):2938-46. PMC: 4657848. DOI: 10.1681/ASN.2015040384. View

Mazurek A, Gryga K, Bugala K, Iwaniec T, Musial J, Podolec P . Influence of statin therapy on antiphospholipid antibodies and endothelial dysfunction in young patients with coronary artery disease and systemic lupus erythematosus. Arch Med Sci. 2022; 18(1):18-24. PMC: 8826879. DOI: 10.5114/aoms.2019.90271. View

Lech M, Anders H . The pathogenesis of lupus nephritis. J Am Soc Nephrol. 2013; 24(9):1357-66. PMC: 3752952. DOI: 10.1681/ASN.2013010026. View

Clark M, Trotter K, Chang A . The Pathogenesis and Therapeutic Implications of Tubulointerstitial Inflammation in Human Lupus Nephritis. Semin Nephrol. 2015; 35(5):455-64. PMC: 4653081. DOI: 10.1016/j.semnephrol.2015.08.007. View

Peoples C, Medsger Jr T, Lucas M, Rosario B, Feghali-Bostwick C . Gender differences in systemic sclerosis: relationship to clinical features, serologic status and outcomes. J Scleroderma Relat Disord. 2017; 1(2):177-240. PMC: 5726425. DOI: 10.5301/jsrd.5000209. View

Zhang W, Yuan M, Hong L, Zhou Q, Yang S, Yang Q . Clinical outcomes of lupus nephritis patients with different proportions of crescents. Lupus. 2016; 25(14):1532-1541. DOI: 10.1177/0961203316642312. View

Bohle A, Wehrmann M, Bogenschutz O, Batz C, VOGL W, Schmitt H . The long-term prognosis of the primary glomerulonephritides. A morphological and clinical analysis of 1747 cases. Pathol Res Pract. 1992; 188(7):908-24. DOI: 10.1016/s0344-0338(11)80252-9. View

Denton C, Lapadula G, Mouthon L, Muller-Ladner U . Renal complications and scleroderma renal crisis. Rheumatology (Oxford). 2009; 48 Suppl 3:iii32-5. DOI: 10.1093/rheumatology/ken483. View

10.

Shimizu T, Iwamoto N, Okamoto M, Endo Y, Tsuji S, Takatani A . Scleroderma Renal Crisis Complicated with Thrombotic Microangiopathy Triggered by Influenza B Virus Infection. Intern Med. 2018; 58(3):441-445. PMC: 6395120. DOI: 10.2169/internalmedicine.1441-18. View

11.

Chen S, Chen H, Liu Z, Zhang H, Hu W, Tang Z . Pathological spectrums and renal prognosis of severe lupus patients with rapidly progressive glomerulonephritis. Rheumatol Int. 2014; 35(4):709-17. DOI: 10.1007/s00296-014-3140-x. View

12.

Laurinavicius A, Rennke H . Collapsing glomerulopathy--a new pattern of renal injury. Semin Diagn Pathol. 2002; 19(3):106-15. View

13.

Walker J, Ahern M, Smith M, Coleman M, Pile K, Rischmueller M . Scleroderma renal crisis: poor outcome despite aggressive antihypertensive treatment. Intern Med J. 2003; 33(5-6):216-20. DOI: 10.1046/j.1445-5994.2003.00358.x. View

14.

Jarrot P, Chiche L, Hervier B, Daniel L, Vuiblet V, Bardin N . Systemic Lupus Erythematosus and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome in Patients With Biopsy-Proven Glomerulonephritis. Medicine (Baltimore). 2016; 95(22):e3748. PMC: 4900711. DOI: 10.1097/MD.0000000000003748. View

15.

Yu F, Haas M, Glassock R, Zhao M . Redefining lupus nephritis: clinical implications of pathophysiologic subtypes. Nat Rev Nephrol. 2017; 13(8):483-495. DOI: 10.1038/nrneph.2017.85. View

16.

Abadeer K, Alsaad A, Geiger X, Porter I . Collapsing glomerulopathy in systemic lupus erythematosus. BMJ Case Rep. 2017; 2017. PMC: 5337646. DOI: 10.1136/bcr-2016-217840. View

17.

Ferraccioli G, Romano G . Renal interstitial cells, proteinuria and progression of lupus nephritis: new frontiers for old factors. Lupus. 2008; 17(6):533-40. DOI: 10.1177/0961203307088002. View

18.

Dube G, Markowitz G, Radhakrishnan J, Appel G, DAgati V . Minimal change disease in systemic lupus erythematosus. Clin Nephrol. 2002; 57(2):120-6. DOI: 10.5414/cnp57120. View

19.

Hsieh C, Chang A, Brandt D, Guttikonda R, Utset T, Clark M . Predicting outcomes of lupus nephritis with tubulointerstitial inflammation and scarring. Arthritis Care Res (Hoboken). 2011; 63(6):865-74. PMC: 3106120. DOI: 10.1002/acr.20441. View

20.

Pokroy-Shapira E, Gelernter I, Molad Y . Evolution of chronic kidney disease in patients with systemic lupus erythematosus over a long-period follow-up: a single-center inception cohort study. Clin Rheumatol. 2014; 33(5):649-57. DOI: 10.1007/s10067-014-2527-0. View