Methylated DNA Markers for Sporadic Colorectal and Endometrial Cancer Are Strongly Associated with Lynch Syndrome Cancers

Overview

Journal Cancer Prev Res (Phila)

Specialty Oncology

Date 2023 Sep 20

PMID 37728516

Authors

Rachel M Bramblet

Jamie N Bakkum-Gamez

Seth W Slettedahl

Patrick H Foote

William R Taylor

Calise K Berger

Brianna J Gysbers

Jacquelyn Arndt

Longwen Chen

Karen A Doering

Kelli N Burger

Douglas W Mahoney

Mark E Sherman

John B Kisiel

N Jewel Samadder

Affiliations

Soon will be listed here.

Abstract

Prevention Relevance: Lynch syndrome (LS) markedly increases risks of colorectal and endometrial cancers. Early detection biomarkers for LS cancers could reduce the needs for invasive screening and surgery. Methylated DNA markers previously identified in sporadic endometrial cancer and colorectal cancer discriminate between benign and cancer tissue in LS.

Citing Articles

Research Progress of DNA Methylation Markers for Endometrial Carcinoma Diagnosis.

Zheng H, Yu C, Yang L, Zhou F, Liu A J Cancer. 2025; 16(3):812-820.

PMID: 39781343 PMC: 11705058. DOI: 10.7150/jca.104214.

Frameshift mutations in peripheral blood as a biomarker for surveillance of Lynch syndrome.

Song Y, Loomans-Kropp H, Baugher R, Somerville B, Baxter S, Kerr T J Natl Cancer Inst. 2024; 116(6):957-965.

PMID: 38466935 PMC: 11160491. DOI: 10.1093/jnci/djae060.

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