Bone Health in Children with Recurrent and Chronic Pancreatitis: A Multi-center Cross Sectional Analysis

Overview

Journal Pancreatology

Specialties Endocrinology
Gastroenterology

Date 2023 Sep 18

PMID 37723006

Authors

Maisam Abu-El-Haija

Lindsey Hornung

Kate Ellery

Douglas S Fishman

Tanja Y Gonska

Cheryl Gariepy

Mark Lowe

Katie Larson Ode

Asim Maqbool

Maria Mascarenhas

Veronique D Morinville

Chee Y Ooi

Emily R Perito

Sarah Jane Schwarzenberg

Zachary M Sellers

Babette S Zemel

Ying Yuan

Fuchenchu Wang

Aliye Uc

Heidi J Kalkwarf

Affiliations

Soon will be listed here.

Abstract

Background/objectives: Bone health of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) is not well studied.

Methods: This retrospective study was performed at three sites and included data from INSPPIRE-2.

Results: Of the 87 children in the study: 46 had ARP (53%), 41 had CP (47%). Mean age was 13.6 ± 3.9 years at last DXA scan. The prevalence of low height-for-age (Z-score < -2) (13%, 10/78) and low bone mineral density (BMD) adjusted for height (Z-score < -2) (6.4%, 5/78) were higher than a healthy reference sample (2.5%, p < 0.0001 and p = 0.03, respectively).

Conclusion: Children with ARP or CP have lower height and BMD than healthy peers. Attention to deficits in growth and bone mineral accrual in children with pancreatic disease is warranted.

Citing Articles

Exocrine Pancreatic Insufficiency in Children - Challenges in Management.

Sankararaman S, Schindler T Pediatric Health Med Ther. 2023; 14:361-378.

PMID: 37908317 PMC: 10615098. DOI: 10.2147/PHMT.S402589.

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