Neurophysiological, Histological, and Behavioral Characterization of Animal Models of Distraction Spinal Cord Injury: a Systematic Review

Overview

Journal Neural Regen Res

Date 2023 Sep 18

PMID 37721285

Authors

Bo Han

Weishi Liang

Yong Hai

Duan Sun

Hongtao Ding

Yihan Yang

Peng Yin

Affiliations

Soon will be listed here.

Abstract

Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity. With the increased degree and duration of distraction, spinal cord injuries become more serious in terms of their neurophysiology, histology, and behavior. Very few studies have been published on the specific characteristics of distraction spinal cord injury. In this study, we systematically review 22 related studies involving animal models of distraction spinal cord injury, focusing particularly on the neurophysiological, histological, and behavioral characteristics of this disease. In addition, we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord injury. We provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research, and provide reference guidelines for the clinical diagnosis and treatment of this disease.

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References

Schwartz D, Auerbach J, Dormans J, Flynn J, Bowe J, Laufer S . Neurophysiological detection of impending spinal cord injury during scoliosis surgery. J Bone Joint Surg Am. 2007; 89(11):2440-9. DOI: 10.2106/JBJS.F.01476. View

Hong J, Suh S, Lee S, Park J, Park S, Rhyu I . Continuous distraction-induced delayed spinal cord injury on motor-evoked potentials and histological changes of spinal cord in a porcine model. Spinal Cord. 2016; 54(9):649-55. DOI: 10.1038/sc.2015.231. View

Shimizu E, Seifert J, Johnson K, Romero-Ortega M . Prophylactic Riluzole Attenuates Oxidative Stress Damage in Spinal Cord Distraction. J Neurotrauma. 2018; 35(12):1319-1328. DOI: 10.1089/neu.2017.5494. View

Skinner S, Transfeldt E . Electromyography in the detection of mechanically induced spinal motor tract injury: observations in diverse porcine models. J Neurosurg Spine. 2009; 11(3):369-74. DOI: 10.3171/2009.3.SPINE08881. View

Guo Y, Hu H, Wang J, Zhang M, Chen K . Walking Function After Cervical Contusion and Distraction Spinal Cord Injuries in Rats. J Exp Neurosci. 2019; 13:1179069519869615. PMC: 6702777. DOI: 10.1177/1179069519869615. View

Tica J, Bradbury E, Didangelos A . Combined Transcriptomics, Proteomics and Bioinformatics Identify Drug Targets in Spinal Cord Injury. Int J Mol Sci. 2018; 19(5). PMC: 5983596. DOI: 10.3390/ijms19051461. View

Kling Jr T, Fergusson N, Leach A, Hensinger R, Lane G, Knight P . The influence of induced hypotension and spine distraction on canine spinal cord blood flow. Spine (Phila Pa 1976). 1985; 10(10):878-83. DOI: 10.1097/00007632-198512000-00003. View

Reames D, Smith J, Fu K, Polly Jr D, Ames C, Berven S . Complications in the surgical treatment of 19,360 cases of pediatric scoliosis: a review of the Scoliosis Research Society Morbidity and Mortality database. Spine (Phila Pa 1976). 2010; 36(18):1484-91. DOI: 10.1097/BRS.0b013e3181f3a326. View

Zhu S, Chen M, Chen M, Ye J, Ying Y, Wu Q . Fibroblast Growth Factor 22 Inhibits ER Stress-Induced Apoptosis and Improves Recovery of Spinal Cord Injury. Front Pharmacol. 2020; 11:18. PMC: 7026669. DOI: 10.3389/fphar.2020.00018. View

10.

Liu K, Dong X, Wang Y, Wu X, Dai H . Dopamine-modified chitosan hydrogel for spinal cord injury. Carbohydr Polym. 2022; 298:120047. DOI: 10.1016/j.carbpol.2022.120047. View

11.

Kigerl K, Gensel J, Ankeny D, Alexander J, Donnelly D, Popovich P . Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci. 2009; 29(43):13435-44. PMC: 2788152. DOI: 10.1523/JNEUROSCI.3257-09.2009. View

12.

Liang W, Han B, Hai Y, Liu Y, Liu X, Yang J . The Role of Microglia/Macrophages Activation and TLR4/NF-κB/MAPK Pathway in Distraction Spinal Cord Injury-Induced Inflammation. Front Cell Neurosci. 2022; 16:926453. PMC: 9218068. DOI: 10.3389/fncel.2022.926453. View

13.

Fouad K, Popovich P, Kopp M, Schwab J . The neuroanatomical-functional paradox in spinal cord injury. Nat Rev Neurol. 2020; 17(1):53-62. PMC: 9012488. DOI: 10.1038/s41582-020-00436-x. View

14.

Tator C . Review of treatment trials in human spinal cord injury: issues, difficulties, and recommendations. Neurosurgery. 2006; 59(5):957-82. DOI: 10.1227/01.NEU.0000245591.16087.89. View

15.

Zhang N, Yin Y, Xu S, Wu Y, Chen W . Inflammation & apoptosis in spinal cord injury. Indian J Med Res. 2012; 135:287-96. PMC: 3361863. View

16.

Martin C, Babin J, Martinez M, CAMIER P, Lorin J, Cazauran J . [Spinal cord (and brain stem) injury at birth (4 cases)]. Arch Fr Pediatr. 1971; 28(9):989-90. View

17.

Li C, Wu Z, Zhou L, Shao J, Hu X, Xu W . Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury. Signal Transduct Target Ther. 2022; 7(1):65. PMC: 8888618. DOI: 10.1038/s41392-022-00885-4. View

18.

Assinck P, Duncan G, Hilton B, Plemel J, Tetzlaff W . Cell transplantation therapy for spinal cord injury. Nat Neurosci. 2017; 20(5):637-647. DOI: 10.1038/nn.4541. View

19.

Page M, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, Mulrow C . The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 372:n71. PMC: 8005924. DOI: 10.1136/bmj.n71. View

20.

Shultz R, Zhong Y . Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury. Neural Regen Res. 2017; 12(5):702-713. PMC: 5461601. DOI: 10.4103/1673-5374.206633. View