Effect of Anti-skin Disorders of Ginsenosides- A Systematic Review

Overview

Journal J Ginseng Res

Date 2023 Sep 18

PMID 37720567

Authors

Lele Cong

Jinli Ma

Yundong Zhang

Yifa Zhou

Xianling Cong

Miao Hao

Affiliations

Soon will be listed here.

Abstract

Ginsenosides are bioactive components of Panax ginseng with many functions such as anti-aging, anti-oxidation, anti-inflammatory, anti-fatigue, and anti-tumor. Ginsenosides are categorized into dammarane, oleanene, and ocotillol type tricyclic triterpenoids based on the aglycon structure. Based on the sugar moiety linked to C-3, C-20, and C-6, C-20, dammarane type was divided into protopanaxadiol (PPD) and protopanaxatriol (PPT). The effects of ginsenosides on skin disorders are noteworthy. They play anti-aging roles by enhancing immune function, resisting melanin formation, inhibiting oxidation, and elevating the concentration of collagen and hyaluronic acid. Thus, ginsenosides have previously been widely used to resist skin diseases and aging. This review details the role of ginsenosides in the anti-skin aging process from mechanisms and experimental research.

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References

Oh Y, Lim H, Park K, Huang Y, Yoon J, Kim K . Ginsenoside Rc protects against UVB‑induced photooxidative damage in epidermal keratinocytes. Mol Med Rep. 2017; 16(3):2907-2914. DOI: 10.3892/mmr.2017.6943. View

Fujimoto J, Sakaguchi H, Aoki I, Toyoki H, Khatun S, Tamaya T . Inhibitory effect of ginsenoside-Rb2 on invasiveness of uterine endometrial cancer cells to the basement membrane. Eur J Gynaecol Oncol. 2002; 22(5):339-41. View

Kim J, Cho S, Kim S, Cho D, Kim S, Park C . Effects of Korean ginseng berry on skin antipigmentation and antiaging via FoxO3a activation. J Ginseng Res. 2017; 41(3):277-283. PMC: 5489743. DOI: 10.1016/j.jgr.2016.05.005. View

Wang H, Zhang S, Zhai L, Sun L, Zhao D, Wang Z . Ginsenoside extract from ginseng extends lifespan and health span in . Food Funct. 2021; 12(15):6793-6808. DOI: 10.1039/d1fo00576f. View

Tang Y, Zhou Y, Wang Y, He Y, Ding J, Li Y . Ginsenoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-SOD2 signaling pathways in a γ-ray irradiation-induced aging mice model. Exp Ther Med. 2020; 20(2):1245-1252. PMC: 7388550. DOI: 10.3892/etm.2020.8810. View

Yoo Y, Lee J, Park S, Nam K, Cho Y, Choi J . Protective effect of ginsenoside-Rb2 from Korean red ginseng on the lethal infection of haemagglutinating virus of Japan in mice. J Ginseng Res. 2013; 37(1):80-6. PMC: 3659615. DOI: 10.5142/jgr.2013.37.80. View

Lee K, Jung T, Lee H, Kim S, Shin Y, Whang W . The antidiabetic effect of ginsenoside Rb2 via activation of AMPK. Arch Pharm Res. 2011; 34(7):1201-8. DOI: 10.1007/s12272-011-0719-6. View

Kang H, Huang Y, Lim H, Shin D, Jang K, Lee Y . Stereospecificity of ginsenoside Rg2 epimers in the protective response against UV-B radiation-induced oxidative stress in human epidermal keratinocytes. J Photochem Photobiol B. 2016; 165:232-239. DOI: 10.1016/j.jphotobiol.2016.10.034. View

Beran F, Kollner T, Gershenzon J, Tholl D . Chemical convergence between plants and insects: biosynthetic origins and functions of common secondary metabolites. New Phytol. 2019; 223(1):52-67. DOI: 10.1111/nph.15718. View

10.

Jesumani V, Du H, Pei P, Aslam M, Huang N . Comparative study on skin protection activity of polyphenol-rich extract and polysaccharide-rich extract from Sargassum vachellianum. PLoS One. 2020; 15(1):e0227308. PMC: 6946147. DOI: 10.1371/journal.pone.0227308. View

11.

Fan H, Wang Y, Zhang X, Chen J, Zhou Q, Yu Z . Ginsenoside compound K ameliorates imiquimod-induced psoriasis-like dermatitis through inhibiting REG3A/RegIIIγ expression in keratinocytes. Biochem Biophys Res Commun. 2019; 515(4):665-671. DOI: 10.1016/j.bbrc.2019.06.007. View

12.

Yang L, Zou H, Gao Y, Luo J, Xie X, Meng W . Insights into gastrointestinal microbiota-generated ginsenoside metabolites and their bioactivities. Drug Metab Rev. 2020; 52(1):125-138. DOI: 10.1080/03602532.2020.1714645. View

13.

Jing H, Li J, Zhang J, Wang W, Li S, Ren Z . The antioxidative and anti-aging effects of acidic- and alkalic-extractable mycelium polysaccharides by Agrocybe aegerita (Brig.) Sing. Int J Biol Macromol. 2017; 106:1270-1278. DOI: 10.1016/j.ijbiomac.2017.08.138. View

14.

Ngo H, Hwang E, Seo S, Yang J, Nguyen Q, Do N . Mixture of enzyme-processed and extract prevents UVB-induced decrease of procollagen type 1 and increase of MMP-1 and IL-6 in human dermal fibroblasts. Biosci Biotechnol Biochem. 2020; 84(11):2327-2336. DOI: 10.1080/09168451.2020.1793657. View

15.

Vaz V, Jardim da Silva L, Geihs M, Maciel F, Nery L, Vargas M . Single and repeated low-dose UVB radiation exposures affect the visual system. J Photochem Photobiol B. 2020; 209:111941. DOI: 10.1016/j.jphotobiol.2020.111941. View

16.

Khavkin J, Ellis D . Aging skin: histology, physiology, and pathology. Facial Plast Surg Clin North Am. 2011; 19(2):229-34. DOI: 10.1016/j.fsc.2011.04.003. View

17.

Lim C, Choi W, Jung H . Stereoselective skin anti-photoaging properties of ginsenoside Rg3 in UV-B-irradiated keratinocytes. Biol Pharm Bull. 2014; 37(10):1583-90. DOI: 10.1248/bpb.b14-00167. View

18.

Mukherjee P, Maity N, Nema N, Sarkar B . Bioactive compounds from natural resources against skin aging. Phytomedicine. 2011; 19(1):64-73. DOI: 10.1016/j.phymed.2011.10.003. View

19.

Zhou J, Gao Y, Yi X, Ding Y . Ginsenoside Rh2 Suppresses Neovascularization in Xenograft Psoriasis Model. Cell Physiol Biochem. 2015; 36(3):980-7. DOI: 10.1159/000430272. View

20.

Kim J, Baek E, Lee E, Yeom M, Park J, Lee K . Ginsenoside F1 attenuates hyperpigmentation in B16F10 melanoma cells by inducing dendrite retraction and activating Rho signalling. Exp Dermatol. 2014; 24(2):150-2. DOI: 10.1111/exd.12586. View