Persistence of Symptoms Following Infection With COVID-19 Among Patients With Type 1 and Type 2 Diabetes Mellitus in Saudi Arabia

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2023 Sep 18

PMID 37719634

Authors

Maram H Abduljabbar

Ghadeer A Alhawsawi

Sarah S Aldharman

Khawlah I Alshahrani

Razan A Alshehri

Abdulmajeed A Alshehri

Abdulrahman T Abukhudair

Maram A AlGhamdi

Affiliations

Soon will be listed here.

Abstract

Background: In Saudi Arabia, information on the persistence of COVID-19-related complications in diabetic patients, their associations with the type of diabetes mellitus (DM), and the role of uncontrolled DM in the complications remains elusive. This study aims to fill this gap. This study aimed to examine the persistence of COVID-19 complications in diabetic patients.

Method: A simple randomized, cross-sectional, questionnaire-based study among patients with type 1 and 2 DM following infection with COVID-19 in Saudi Arabia.

Result: In the present study, a total of 674 participants were included. Among the COVID-19 symptoms, fatigue (65.6%) was reported the most frequently, followed by headache (62.3%) and cough (59.8%). About 44% of patients reported high blood sugar levels, including 25.5% with elevated fasting (>126 mg/dL) and 18.5% with elevated postprandial (>200 mg/dL) glucose levels. We also report that age > 55 years [OR= 1.66 (1.01-2.56), p=0.045], anti-diabetic medications [OR= 2.10 (1.82-3.91), p=0.022], multiple comorbidities [OR= 3.21 (1.98-4.85), p=0.005], chest pain [OR= 2.54 (0.96-3.81), p=0.003], and joint pain [OR= 1.64 (0.73-2.94), p=0.025] were independently associated with COVID-19-related complications in diabetic patients.

Conclusion: The most common persistent symptoms in diabetic patients with COVID-19 infection are fatigue, headaches, and cough. Advanced age and use of antidiabetic medications were independently associated with COVID-19-related complications in diabetic patients.

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References

Han Q, Zheng B, Daines L, Sheikh A . Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms. Pathogens. 2022; 11(2). PMC: 8875269. DOI: 10.3390/pathogens11020269. View

Sudre C, Murray B, Varsavsky T, Graham M, Penfold R, Bowyer R . Attributes and predictors of long COVID. Nat Med. 2021; 27(4):626-631. PMC: 7611399. DOI: 10.1038/s41591-021-01292-y. View

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J . A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020; 382(8):727-733. PMC: 7092803. DOI: 10.1056/NEJMoa2001017. View

Bepouka B, Odio O, Mangala D, Mayasi N, Mandina M, Longokolo M . Diabetes Mellitus is Associated With Higher COVID-19 Mortality Rates in Sub-Saharan Africa: A Systematic Review and Meta-analysis. Cureus. 2022; 14(7):e26877. PMC: 9375835. DOI: 10.7759/cureus.26877. View

Nassar M, Daoud A, Nso N, Medina L, Ghernautan V, Bhangoo H . Diabetes Mellitus and COVID-19: Review Article. Diabetes Metab Syndr. 2021; 15(6):102268. PMC: 8416292. DOI: 10.1016/j.dsx.2021.102268. View

Chakraborty C, Sharma A, Bhattacharya M, Sharma G, Agoramoorthy G, Lee S . Diabetes and COVID-19: a major challenge in pandemic period?. Eur Rev Med Pharmacol Sci. 2020; 24(21):11409-11420. DOI: 10.26355/eurrev_202011_23634. View

Ceriello A, Standl E, Catrinoiu D, Itzhak B, Lalic N, Rahelic D . Issues for the management of people with diabetes and COVID-19 in ICU. Cardiovasc Diabetol. 2020; 19(1):114. PMC: 7370631. DOI: 10.1186/s12933-020-01089-2. View

Mirzaei M, Rahmaninan M, Mirzaei M, Nadjarzadeh A, Dehghani Tafti A . Epidemiology of diabetes mellitus, pre-diabetes, undiagnosed and uncontrolled diabetes in Central Iran: results from Yazd health study. BMC Public Health. 2020; 20(1):166. PMC: 6998152. DOI: 10.1186/s12889-020-8267-y. View

Deshpande A, Harris-Hayes M, Schootman M . Epidemiology of diabetes and diabetes-related complications. Phys Ther. 2008; 88(11):1254-64. PMC: 3870323. DOI: 10.2522/ptj.20080020. View

10.

Vellanki P, Umpierrez G . Diabetic ketoacidosis risk during the COVID-19 pandemic. Lancet Diabetes Endocrinol. 2021; 9(10):643-644. PMC: 8412797. DOI: 10.1016/S2213-8587(21)00241-2. View

11.

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y . Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020; 395(10223):507-513. PMC: 7135076. DOI: 10.1016/S0140-6736(20)30211-7. View

12.

Gazzaz Z . Diabetes and COVID-19. Open Life Sci. 2021; 16(1):297-302. PMC: 8010370. DOI: 10.1515/biol-2021-0034. View

13.

Logue J, Franko N, McCulloch D, McDonald D, Magedson A, Wolf C . Sequelae in Adults at 6 Months After COVID-19 Infection. JAMA Netw Open. 2021; 4(2):e210830. PMC: 7896197. DOI: 10.1001/jamanetworkopen.2021.0830. View

14.

Abdi A, Jalilian M, Sarbarzeh P, Vlaisavljevic Z . Diabetes and COVID-19: A systematic review on the current evidences. Diabetes Res Clin Pract. 2020; 166:108347. PMC: 7375314. DOI: 10.1016/j.diabres.2020.108347. View

15.

Unnikrishnan R, Misra A . Diabetes and COVID19: a bidirectional relationship. Nutr Diabetes. 2021; 11(1):21. PMC: 8223528. DOI: 10.1038/s41387-021-00163-2. View

16.

Majumder J, Minko T . Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19. AAPS J. 2021; 23(1):14. PMC: 7784226. DOI: 10.1208/s12248-020-00532-2. View

17.

Nafakhi H, Alareedh M, Al-Buthabhak K, Shaghee F, Nafakhi A, Kasim S . Predictors of adverse in-hospital outcome and recovery in patients with diabetes mellitus and COVID-19 pneumonia in Iraq. Diabetes Metab Syndr. 2020; 15(1):33-38. PMC: 7832757. DOI: 10.1016/j.dsx.2020.12.014. View

18.

Shi Q, Zhang X, Jiang F, Zhang X, Hu N, Bimu C . Clinical Characteristics and Risk Factors for Mortality of COVID-19 Patients With Diabetes in Wuhan, China: A Two-Center, Retrospective Study. Diabetes Care. 2020; 43(7):1382-1391. DOI: 10.2337/dc20-0598. View

19.

Winer N, Sowers J . Epidemiology of diabetes. J Clin Pharmacol. 2004; 44(4):397-405. DOI: 10.1177/0091270004263017. View

20.

Ghosh A, Anjana R, Shanthi Rani C, Jeba Rani S, Gupta R, Jha A . Glycemic parameters in patients with new-onset diabetes during COVID-19 pandemic are more severe than in patients with new-onset diabetes before the pandemic: NOD COVID India Study. Diabetes Metab Syndr. 2021; 15(1):215-220. PMC: 7771314. DOI: 10.1016/j.dsx.2020.12.033. View