Pituitary Crosstalk with Bone, Adipose Tissue and Brain

Overview

Journal Nat Rev Endocrinol

Specialty Endocrinology

Date 2023 Sep 15

PMID 37715028

Authors

Mone Zaidi

Tony Yuen

Se-Min Kim

Affiliations

Soon will be listed here.

Abstract

Traditional textbook physiology has ascribed unitary functions to hormones from the anterior and posterior pituitary gland, mainly in the regulation of effector hormone secretion from endocrine organs. However, the evolutionary biology of pituitary hormones and their receptors provides evidence for a broad range of functions in vertebrate physiology. Over the past decade, we and others have discovered that thyroid-stimulating hormone, follicle-stimulating hormone, adrenocorticotropic hormone, prolactin, oxytocin and arginine vasopressin act directly on somatic organs, including bone, adipose tissue and liver. New evidence also indicates that pituitary hormone receptors are expressed in brain regions, nuclei and subnuclei. These studies have prompted us to attribute the pathophysiology of certain human diseases, including osteoporosis, obesity and neurodegeneration, at least in part, to changes in pituitary hormone levels. This new information has identified actionable therapeutic targets for drug discovery.

Citing Articles

Effect of Thyroid Status Modulation on Pituitary and Peripheral Hormone Concentrations in Healthy Older Subjects.

van der Spoel E, Cornet S, Zutinic A, Ballieux B, Slagboom P, Pijl H Neuroendocrinology. 2024; 115(1):1-12.

PMID: 39626644 PMC: 11854971. DOI: 10.1159/000542832.

Pituitary whole transcriptome analysis reveals key genes regulating reproduction in Hy-Line Brown hens and the construction of their ceRNA molecular regulatory network.

Li Y, Zhai B, Song H, Zhang X, Tian Y, Li D BMC Genomics. 2024; 25(1):1100.

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Prolactin deficiency drives diabetes-associated cognitive dysfunction by inducing microglia-mediated synaptic loss.

Jiang J, Zhang P, Yuan Y, Xu X, Wu T, Zhang Z J Neuroinflammation. 2024; 21(1):295.

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Modern approach to bone comorbidity in prolactinoma.

Uygur M, Menotti S, Santoro S, Giustina A Pituitary. 2024; 27(6):802-812.

PMID: 39541075 DOI: 10.1007/s11102-024-01469-x.

Prolactin: structure, receptors, and functions.

Chasseloup F, Bernard V, Chanson P Rev Endocr Metab Disord. 2024; 25(6):953-966.

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