Expression in Escherichia Coli of Hepatitis B Virus DNA Sequences Cloned in Plasmid PBR322

Overview

Journal Nature

Specialty Science

Date 1979 May 3

PMID 377093

Citations 62

Authors

C J Burrell

P MacKay

P J Greenaway

P H Hofschneider

K Murray

Affiliations

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Abstract

Fragments of hepatitis B virus DNA isolated from Dane particles have been inserted into the Escherichia coli plasmid pBR322 and cloned. Cells carrying the hybrid plasmid synthesise antigenic material that reacts specifically with antisera to hepatitis B viral antigens.

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