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Early Clinical Experience with a Degraded 4 MeV Electron Beam in Radiotherapy of Superficial Basal Cell Carcinoma

Overview
Specialty Oncology
Date 2023 Sep 14
PMID 37705728
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Abstract

The most common non-melanoma skin cancer is basal cell carcinoma (BCC). Surgery is the gold standard treatment but also non-surgical alternatives are needed. The purpose of this work was to present the early clinical experiences of degraded 4 MeV electron beam as a treatment method for superficial BCC. Twelve patients underwent two weeks radiation therapy treatment with either 5 × 7 Gy or 2 × 12 Gy. There were no significant differences in treatment outcome with different fractionations or lesion locations. The degraded beam method is a safe and valid non-surgical solution for suitable patients with superficial lesions.

References
1.
Gianfaldoni S, Gianfaldoni R, Wollina U, Lotti J, Tchernev G, Lotti T . An Overview on Radiotherapy: From Its History to Its Current Applications in Dermatology. Open Access Maced J Med Sci. 2017; 5(4):521-525. PMC: 5535674. DOI: 10.3889/oamjms.2017.122. View

2.
Valve A, Kulmala A, Followill D, Tenhunen M . Modification of the 4 MeV electron beam from a linear accelerator for irradiation of small superficial skin tumors. Phys Imaging Radiat Oncol. 2021; 10:25-28. PMC: 7807873. DOI: 10.1016/j.phro.2019.04.003. View

3.
Guinot J, Rembielak A, Perez-Calatayud J, Rodriguez-Villalba S, Skowronek J, Tagliaferri L . GEC-ESTRO ACROP recommendations in skin brachytherapy. Radiother Oncol. 2018; 126(3):377-385. DOI: 10.1016/j.radonc.2018.01.013. View

4.
Kim J, Kozlow J, Mittal B, Moyer J, Olencki T, Rodgers P . Guidelines of care for the management of basal cell carcinoma. J Am Acad Dermatol. 2018; 78(3):540-559. DOI: 10.1016/j.jaad.2017.10.006. View

5.
Drucker A, Adam G, Rofeberg V, Gazula A, Smith B, Moustafa F . Treatments of Primary Basal Cell Carcinoma of the Skin: A Systematic Review and Network Meta-analysis. Ann Intern Med. 2018; 169(7):456-466. DOI: 10.7326/M18-0678. View