Investigating a Causal Role for Lung Microbiome Dysbiosis in Early Chronic Obstructive Pulmonary Disease Pathogenesis

Overview

Journal Am J Respir Crit Care Med

Specialty Critical Care

Date 2023 Sep 13

PMID 37703423

Authors

Alexa A Pragman

Affiliations

Soon will be listed here.

References

Opron K, Begley L, Erb-Downward J, Freeman C, Madapoosi S, Alexis N . Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort. NPJ Biofilms Microbiomes. 2021; 7(1):14. PMC: 7865064. DOI: 10.1038/s41522-021-00185-9. View

Liang W, Yang Y, Gong S, Wei M, Ma Y, Feng R . Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease. Cell Host Microbe. 2023; 31(6):1054-1070.e9. DOI: 10.1016/j.chom.2023.04.018. View

Wu B, Sulaiman I, Tsay J, Perez L, Franca B, Li Y . Episodic Aspiration with Oral Commensals Induces a MyD88-dependent, Pulmonary T-Helper Cell Type 17 Response that Mitigates Susceptibility to . Am J Respir Crit Care Med. 2020; 203(9):1099-1111. PMC: 8314894. DOI: 10.1164/rccm.202005-1596OC. View

Ghorani V, Boskabady M, Khazdair M, Kianmeher M . Experimental animal models for COPD: a methodological review. Tob Induc Dis. 2017; 15:25. PMC: 5414171. DOI: 10.1186/s12971-017-0130-2. View

Madapoosi S, Cruickshank-Quinn C, Opron K, Erb-Downward J, Begley L, Li G . Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022; 206(4):427-439. PMC: 11418810. DOI: 10.1164/rccm.202110-2241OC. View

Wright J, Cosio M, Churg A . Animal models of chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2008; 295(1):L1-15. PMC: 2494776. DOI: 10.1152/ajplung.90200.2008. View

Mayhew D, Devos N, Lambert C, Brown J, Clarke S, Kim V . Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations. Thorax. 2018; 73(5):422-430. PMC: 5909767. DOI: 10.1136/thoraxjnl-2017-210408. View

Tsay J, Wu B, Sulaiman I, Gershner K, Schluger R, Li Y . Lower Airway Dysbiosis Affects Lung Cancer Progression. Cancer Discov. 2020; 11(2):293-307. PMC: 7858243. DOI: 10.1158/2159-8290.CD-20-0263. View

Ramsheh M, Haldar K, Esteve-Codina A, Purser L, Richardson M, Muller-Quernheim J . Lung microbiome composition and bronchial epithelial gene expression in patients with COPD versus healthy individuals: a bacterial 16S rRNA gene sequencing and host transcriptomic analysis. Lancet Microbe. 2022; 2(7):e300-e310. DOI: 10.1016/S2666-5247(21)00035-5. View

10.

Sulaiman I, Wu B, Chung M, Isaacs B, Tsay J, Holub M . Lower Airway Dysbiosis Augments Lung Inflammatory Injury in Mild-to-Moderate Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2023; 208(10):1101-1114. PMC: 10867925. DOI: 10.1164/rccm.202210-1865OC. View

11.

Wang Z, Locantore N, Haldar K, Ramsheh M, Beech A, Ma W . Inflammatory Endotype-associated Airway Microbiome in Chronic Obstructive Pulmonary Disease Clinical Stability and Exacerbations: A Multicohort Longitudinal Analysis. Am J Respir Crit Care Med. 2020; 203(12):1488-1502. PMC: 8483235. DOI: 10.1164/rccm.202009-3448OC. View

12.

Wang Z, Singh R, Miller B, Tal-Singer R, Van Horn S, Tomsho L . Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study. Thorax. 2017; 73(4):331-338. DOI: 10.1136/thoraxjnl-2017-210741. View