A Case of Histological Diagnosis of Myositis in a Person Living with HIV

Overview

Journal Infez Med

Specialty Infectious Diseases

Date 2023 Sep 13

PMID 37701394

Authors

Ilaria De Benedetto

Francesco Biagini

Guido Urbano

Tiziana Enrica Mongini

Ilaria Cassetta

Luca Scaglione

Antonio Curtoni

Guido Calleri

Andrea Calcagno

Francesco Giuseppe De Rosa

Silvia Corcione

Affiliations

Soon will be listed here.

Abstract

We report the case of a 58-year-old male with a recent diagnosis of HIV infection admitted for progressive muscular weakness and psychomotor impairment. Cerebrospinal examination documented a mild hyperproteinorrachia, with normal cells count and reduced glycorrhachia. Brain gadolinium-enhanced MRI showed bilateral T2 and FLAIR hyperintensities in the nucleo-capsular region and irregular contrast-enhancement of the and the right putamen. The histologic analysis of a quadriceps biopsy showed several foci of inflammatory infiltrates with concomitant muscular fiber atrophy and degeneration. Scattered intracytoplasmic inclusions were observed in muscle fibers, representing the main pathological feature. A positive PCR for and a specific monoclonal antibody immunohistochemical staining confirmed the diagnosis.

References

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