Facile One-pot Hydrothermal Synthesis of a Zinc Oxide/curcumin Nanocomposite with Enhanced Toxic Activity Against Breast Cancer Cells

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2023 Sep 13

PMID 37701282

Authors

Lorenzo Francesco Madeo

Christine Schirmer

Giuseppe Cirillo

Samuel Froeschke

Martin Hantusch

Manuela Curcio

Fiore Pasquale Nicoletta

Bernd Buchner

Michael Mertig

Silke Hampel

Affiliations

Soon will be listed here.

Abstract

Zinc oxide/Curcumin (Zn(CUR)O) nanocomposites were prepared hydrothermal treatment of Zn(NO) in the presence of hexamethylenetetramine as a stabilizing agent and CUR as a bioactive element. Three ZnO : CUR ratios were investigated, namely 57 : 43 (Zn(CUR)O-A), 60 : 40 (Zn(CUR)O-B) and 81 : 19 (Zn(CUR)O-C), as assessed by thermogravimetric analyses, with an average hydrodynamic diameter of nanoaggregates in the range of 223 to 361 nm. The interaction of CUR with ZnO hydroxyl and ketoenol groups (as proved by X-ray photoelectron spectroscopy analyses) was found to significantly modify the key properties of ZnO nanoparticles with the obtainment of a bilobed shape (as shown by scanning electron microscopy), and influenced the growth process of the composite nanoparticles as indicated by the varying particle sizes determined by powder X-ray diffraction. The efficacy of Zn(CUR)O as anticancer agents was evaluated on MCF-7 and MDA-MB-231 cancer cells, obtaining a synergistic activity with a cell viability depending on the CUR amount within the nanocomposite. Finally, the determination of reactive oxygen species production in the presence of Zn(CUR)O was used as a preliminary evaluation of the mechanism of action of the nanocomposites.

Citing Articles

ZnO-Graphene Oxide Nanocomposite for Paclitaxel Delivery and Enhanced Toxicity in Breast Cancer Cells.

Madeo L, Schirmer C, Cirillo G, Asha A, Ghunaim R, Froeschke S Molecules. 2024; 29(16).

PMID: 39202850 PMC: 11357239. DOI: 10.3390/molecules29163770.

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