Association Between Choline Supplementation and Alzheimer's Disease Risk: a Systematic Review Protocol

Overview

Journal Front Aging Neurosci

Specialty Geriatrics

Date 2023 Sep 13

PMID 37700814

Authors

Sixtus Aguree

Maryam Zolnoori

Thea Patricia Atwood

Arthur Owora

Affiliations

Soon will be listed here.

Abstract

Background And Aims: There is growing evidence suggesting choline intake might have beneficial effects on cognitive function in the elderly. However, some studies report no relationship between choline intake and cognitive function or improvement in Alzheimer's disease patients. This protocol is for a systematic review of choline intake and Alzheimer's disease that aims to assess the comparative clinical effectiveness of choline supplementation on Alzheimer's disease risk.

Methods And Analysis: literature search will be performed in PubMed, MEDLINE, EMBASE, CINAHL, Scopus, Cochrane, and the Web of Science electronic databases from inception until October 2023. We will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies will be included if they compared two different time points of choline biomarkers measures in men or women (65+) with Alzheimer's Disease. The risk of bias in the included studies will be assessed within the Covidence data-management software.

Results: This review will summarize the clinical trial and quasi-experimental evidence of choline intake on Alzheimer's disease risk for adults aged 65+. The results from all eligible studies included in the analysis will be presented in tables, text, and figures. A descriptive synthesis will present the characteristics of included studies (e.g., age, sex of participants, type, length of intervention and comparator, and outcome measures), critical appraisal results, and descriptions of the main findings.

Discussion: This systematic review will summarize the existing evidence on the association between Choline intake and AD and to make recommendations if appropriate. The results of this review will be considered with respect to whether there is enough evidence of benefit to merit a more definitive randomized controlled trial. The results will be disseminated through peer-reviewed journals population.

Conclusion: This protocol outlines the methodology for a systematic review of choline intake and AD. The resulting systematic review from this protocol will form an evidence-based foundation to advance nutrition care for individuals with AD or poor cognitive function.

Systematic Review Registration: http://www.crd.york.ac.uk/PROSPERO, identifier CRD42023395004.

Citing Articles

Treatments and regulatory mechanisms of acoustic stimuli on mood disorders and neurological diseases.

Chen Y, Sun J, Tao J, Sun T Front Neurosci. 2024; 17:1322486.

PMID: 38249579 PMC: 10796816. DOI: 10.3389/fnins.2023.1322486.

References

Ueland P, Holm P, Hustad S . Betaine: a key modulator of one-carbon metabolism and homocysteine status. Clin Chem Lab Med. 2005; 43(10):1069-75. DOI: 10.1515/CCLM.2005.187. View

Mosconi L, McHugh P . Let Food Be Thy Medicine: Diet, Nutrition, and Biomarkers' Risk of Alzheimer's Disease. Curr Nutr Rep. 2015; 4(2):126-135. PMC: 4497956. DOI: 10.1007/s13668-014-0111-5. View

Jack Jr C, Albert M, Knopman D, McKhann G, Sperling R, Carrillo M . Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011; 7(3):257-62. PMC: 3096735. DOI: 10.1016/j.jalz.2011.03.004. View

Yuan J, Liu X, Liu C, Ang A, Massaro J, Devine S . Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study. Am J Clin Nutr. 2023; 116(5):1201-1207. PMC: 9630864. DOI: 10.1093/ajcn/nqac193. View

Dubois B, Hampel H, Feldman H, Scheltens P, Aisen P, Andrieu S . Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria. Alzheimers Dement. 2016; 12(3):292-323. PMC: 6417794. DOI: 10.1016/j.jalz.2016.02.002. View

van den Brink A, Brouwer-Brolsma E, Berendsen A, van de Rest O . The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer's Disease-A Review. Adv Nutr. 2019; 10(6):1040-1065. PMC: 6855954. DOI: 10.1093/advances/nmz054. View

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan E . Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984; 34(7):939-44. DOI: 10.1212/wnl.34.7.939. View

Higgins J, Flicker L . Lecithin for dementia and cognitive impairment. Cochrane Database Syst Rev. 2003; (3):CD001015. DOI: 10.1002/14651858.CD001015. View

Brookmeyer R, Abdalla N, Kawas C, Corrada M . Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States. Alzheimers Dement. 2017; 14(2):121-129. PMC: 5803316. DOI: 10.1016/j.jalz.2017.10.009. View

10.

Sperling R, Aisen P, Beckett L, Bennett D, Craft S, Fagan A . Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011; 7(3):280-92. PMC: 3220946. DOI: 10.1016/j.jalz.2011.03.003. View

11.

Hebert L, Weuve J, Scherr P, Evans D . Alzheimer disease in the United States (2010-2050) estimated using the 2010 census. Neurology. 2013; 80(19):1778-83. PMC: 3719424. DOI: 10.1212/WNL.0b013e31828726f5. View

12.

Buchman A, Sohel M, Brown M, JENDEN D, Ahn C, Roch M . Verbal and visual memory improve after choline supplementation in long-term total parenteral nutrition: a pilot study. JPEN J Parenter Enteral Nutr. 2001; 25(1):30-5. DOI: 10.1177/014860710102500130. View

13.

Whiley L, Sen A, Heaton J, Proitsi P, Garcia-Gomez D, Leung R . Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease. Neurobiol Aging. 2013; 35(2):271-8. PMC: 5866043. DOI: 10.1016/j.neurobiolaging.2013.08.001. View

14.

Wang Y, Guan X, Chen X, Cai Y, Ma Y, Ma J . Choline Supplementation Ameliorates Behavioral Deficits and Alzheimer's Disease-Like Pathology in Transgenic APP/PS1 Mice. Mol Nutr Food Res. 2019; 63(18):e1801407. DOI: 10.1002/mnfr.201801407. View

15.

Nurk E, Refsum H, Bjelland I, Drevon C, Tell G, Ueland P . Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. Br J Nutr. 2012; 109(3):511-9. DOI: 10.1017/S0007114512001249. View

16.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

17.

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009; 6(7):e1000100. PMC: 2707010. DOI: 10.1371/journal.pmed.1000100. View

18.

Albert M, DeKosky S, Dickson D, Dubois B, Feldman H, Fox N . The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011; 7(3):270-9. PMC: 3312027. DOI: 10.1016/j.jalz.2011.03.008. View

19.

Dubois B, Feldman H, Jacova C, DeKosky S, Barberger-Gateau P, Cummings J . Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007; 6(8):734-46. DOI: 10.1016/S1474-4422(07)70178-3. View

20.

de Jager C . Critical levels of brain atrophy associated with homocysteine and cognitive decline. Neurobiol Aging. 2014; 35 Suppl 2:S35-9. DOI: 10.1016/j.neurobiolaging.2014.03.040. View