A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts

Overview

Journal Diabetes

Specialty Endocrinology

Date 2023 Sep 12

PMID 37699401

Authors

Ana Nogal

Francesca Tettamanzi

Qiuling Dong

Panayiotis Louca

Alessia Visconti

Colette Christiansen

Taylor Breuninger

Jakob Linseisen

Harald Grallert

Nina Wawro

Francesco Asnicar

Kari Wong

Andrei-Florin Baleanu

Gregory A Michelotti

Nicola Segata

Mario Falchi

Annette Peters

Paul W Franks

Vincenzo Bagnardi

Tim D Spector

Jordana T Bell

Christian Gieger

Ana M Valdes

Cristina Menni

Affiliations

Soon will be listed here.

Abstract

Article Highlights: Prediabetes is a metabolic condition associated with gut microbiome composition, although mechanisms remain elusive. We investigated whether there is a fecal metabolite signature of impaired fasting glucose (IFG) and the possible underlying mechanisms of action. We identified a fecal metabolite signature of IFG associated with prevalent IFG in two independent cohorts and incident type 2 diabetes in a subanalysis. Although the signature consists of metabolites of nonmicrobial origin, it is strongly correlated with gut microbiome composition. Fecal metabolites enable modeling of another mechanism of gut microbiome effect on prediabetes by affecting intestinal absorption or excretion of host compounds and xenobiotics.

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