Calorie Restriction Outperforms Bariatric Surgery in a Murine Model of Obesity and Triple-negative Breast Cancer

Overview

Journal JCI Insight

Specialties Biomedical Engineering
General Medicine

Date 2023 Sep 12

PMID 37698918

Authors

Kristina K Camp

Michael F Coleman

Tori L McFarlane

Steven S Doerstling

Subreen A Khatib

Erika T Rezeli

Alfor G Lewis

Alexander J Pfeil

Laura A Smith

Laura W Bowers

Farnaz Fouladi

Weida Gong

Elaine M Glenny

Joel S Parker

Ginger L Milne

Ian M Carroll

Anthony A Fodor

Randy J Seeley

Stephen D Hursting

Affiliations

Soon will be listed here.

Abstract

Obesity promotes triple-negative breast cancer (TNBC), and effective interventions are urgently needed to break the obesity-TNBC link. Epidemiologic studies indicate that bariatric surgery reduces TNBC risk, while evidence is limited or conflicted for weight loss via low-fat diet (LFD) or calorie restriction (CR). Using a murine model of obesity-driven TNBC, we compared the antitumor effects of vertical sleeve gastrectomy (VSG) with LFD, chronic CR, and intermittent CR. Each intervention generated weight and fat loss and suppressed tumor growth relative to obese mice (greatest suppression with CR). VSG and CR regimens exerted both similar and unique effects, as assessed using multiomics approaches, in reversing obesity-associated transcript, epigenetics, secretome, and microbiota changes and restoring antitumor immunity. Thus, in a murine model of TNBC, bariatric surgery and CR each reverse obesity-driven tumor growth via shared and distinct antitumor mechanisms, and CR is superior to VSG in reversing obesity's procancer effects.

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