Associations Between GrimAge Acceleration and Pulmonary Function in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Overview

Journal Epigenomics

Specialty Genetics

Date 2023 Sep 11

PMID 37694401

Authors

Brian T Joyce

Xuefen Chen

Tao Gao

Yinan Zheng

Drew R Nannini

Lei Liu

Benjamin E Henkle

Ravi Kalhan

George Washko

Ken M Kunisaki

Bharat Thyagarajan

Douglas E Vaughan

Myron Gross

David R Jacobs Jr

Donald Lloyd-Jones

Lifang Hou

Affiliations

Soon will be listed here.

Abstract

The objective of this research was to determine whether pulmonary function is associated with epigenetic aging (GrimAge) and whether GrimAge predicts emphysema. This prospective study examined 1042 participants enrolled as part of a community-based longitudinal cohort. The cross-sectional associations between pulmonary function and GrimAge, measured at study year (Y) 20 (participant ages 40-45 years), and prospective associations with emphysema at Y25 were examined. At Y20, forced expiratory volume in 1 s (FEV) and FEV/forced vital capacity (FVC) were negatively associated with GrimAge; for Y0-Y10 cumulative measures, only the FEV/FVC ratio was associated with GrimAge at Y15 and Y20. Emphysema at Y25 was associated with GrimAge at Y15 and Y20. Pulmonary function was associated with GrimAge during early and mid-life; GrimAge partially mediated the association between pulmonary function and emphysema.

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