Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma

Overview

Journal J Pharm Bioallied Sci

Specialty Pharmacology

Date 2023 Sep 11

PMID 37694019

Authors

Harish A Kumar

Anupama Desai

Gouse Mohiddin

Pallavi Mishra

Arnab Bhattacharyya

Roquaiya Nishat

Affiliations

Soon will be listed here.

Abstract

Cancer stem cells (CSCs) are a small sub-population of cells within a tumor mass proficient of tumor initiation and progression. Distinguishing features possessed by CSCs encompass self-renewal, regeneration and capacity to differentiate. These cells are attributed to the phenomenon of aggression, recurrence and metastasis in neoplasms. Due to their cancer initiating and contributing features, a proper understanding of these CSCs and its microenvironment would aid in better understanding of cancer and designing better targeted therapeutic strategies for improved clinical outcome, thus improving the prognosis. This article dispenses a narrative review of CSCs in the context of head and neck carcinoma under the sub headings of overview of cancer stem cells, methods of isolation of these cells, putative CSC markers of head and neck cancer, signaling pathways used by these cells and their therapeutic implications.

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References

Lim Y, Han J, Kang H, Kim Y, Lee B, Choi E . Overexpression of c-Met promotes invasion and metastasis of small oral tongue carcinoma. Oral Oncol. 2012; 48(11):1114-9. DOI: 10.1016/j.oraloncology.2012.05.013. View

Lee H, Kang Y, Lee J, Byun J, Kim U, Jang S . Positive expression of NANOG, mutant p53, and CD44 is directly associated with clinicopathological features and poor prognosis of oral squamous cell carcinoma. BMC Oral Health. 2015; 15(1):153. PMC: 4667499. DOI: 10.1186/s12903-015-0120-9. View

Nishat R, Sundar Behura S, Ramachandra S, Kumar H, Bandyopadhyay A . Human Papilloma Virus (HPV) Induced Head & Neck Squamous Cell Carcinoma: A Comprehensive Retrospect. J Clin Diagn Res. 2015; 9(6):ZE01-4. PMC: 4525625. DOI: 10.7860/JCDR/2015/13948.6056. View

Shay J, Wright W . Telomeres and telomerase in normal and cancer stem cells. FEBS Lett. 2010; 584(17):3819-25. PMC: 3370416. DOI: 10.1016/j.febslet.2010.05.026. View

Hayry V, Makinen L, Atula T, Sariola H, Makitie A, Leivo I . Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue. Br J Cancer. 2010; 102(5):892-7. PMC: 2833245. DOI: 10.1038/sj.bjc.6605544. View

Baumann P, Cremers N, Kroese F, Orend G, Chiquet-Ehrismann R, Uede T . CD24 expression causes the acquisition of multiple cellular properties associated with tumor growth and metastasis. Cancer Res. 2005; 65(23):10783-93. DOI: 10.1158/0008-5472.CAN-05-0619. View

Yu C, Hu F, Yu C, Chou M . Targeting CD133 in the enhancement of chemosensitivity in oral squamous cell carcinoma-derived side population cancer stem cells. Head Neck. 2014; 38 Suppl 1:E231-8. DOI: 10.1002/hed.23975. View

Chen C, Wei Y, Hummel M, Hoffmann T, Gross M, Kaufmann A . Evidence for epithelial-mesenchymal transition in cancer stem cells of head and neck squamous cell carcinoma. PLoS One. 2011; 6(1):e16466. PMC: 3029362. DOI: 10.1371/journal.pone.0016466. View

Ge N, Lin H, Xiao X, Guo L, Xu H, Wang X . Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma. J Transl Med. 2010; 8:94. PMC: 2958910. DOI: 10.1186/1479-5876-8-94. View

10.

Fukusumi T, Ishii H, Konno M, Yasui T, Nakahara S, Takenaka Y . CD10 as a novel marker of therapeutic resistance and cancer stem cells in head and neck squamous cell carcinoma. Br J Cancer. 2014; 111(3):506-14. PMC: 4119971. DOI: 10.1038/bjc.2014.289. View

11.

Chou M, Hu F, Yu C, Yu C . Sox2 expression involvement in the oncogenicity and radiochemoresistance of oral cancer stem cells. Oral Oncol. 2014; 51(1):31-9. DOI: 10.1016/j.oraloncology.2014.10.002. View

12.

Chen D, Wang C . Targeting cancer stem cells in squamous cell carcinoma. Precis Clin Med. 2019; 2(3):152-165. PMC: 6770277. DOI: 10.1093/pcmedi/pbz016. View

13.

Liu W, Feng J, Shen X, Wang H, Liu Y, Zhou Z . Two stem cell markers, ATP-binding cassette, G2 subfamily (ABCG2) and BMI-1, predict the transformation of oral leukoplakia to cancer: a long-term follow-up study. Cancer. 2011; 118(6):1693-700. DOI: 10.1002/cncr.26483. View

14.

Prince M, Ailles L . Cancer stem cells in head and neck squamous cell cancer. J Clin Oncol. 2008; 26(17):2871-5. DOI: 10.1200/JCO.2007.15.1613. View

15.

Swain S, Nishat R, Ramachandran S, Raghuvanshi M, Sundar Behura S, Kumar H . Comparative evaluation of immunohistochemical expression of MCM2 and Ki67 in oral epithelial dysplasia and oral squamous cell carcinoma. J Cancer Res Ther. 2022; 18(4):997-1002. DOI: 10.4103/jcrt.JCRT_10_20. View

16.

Kulsum S, Sudheendra H, Pandian R, Ravindra D, Siddappa G, R N . Cancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by aldehyde dehydrogenase 1 A1 inhibition. Mol Carcinog. 2016; 56(2):694-711. DOI: 10.1002/mc.22526. View

17.

Irani S, Jafari B . Expression of vimentin and CD44 in mucoepidermoid carcinoma: A role in tumor growth. Indian J Dent Res. 2018; 29(3):333-340. DOI: 10.4103/ijdr.IJDR_184_17. View

18.

McCullough M, Prasad G, Farah C . Oral mucosal malignancy and potentially malignant lesions: an update on the epidemiology, risk factors, diagnosis and management. Aust Dent J. 2010; 55 Suppl 1:61-5. DOI: 10.1111/j.1834-7819.2010.01200.x. View

19.

Major A, Pitty L, Farah C . Cancer stem cell markers in head and neck squamous cell carcinoma. Stem Cells Int. 2013; 2013:319489. PMC: 3603684. DOI: 10.1155/2013/319489. View

20.

Kuhn N, Tuan R . Regulation of stemness and stem cell niche of mesenchymal stem cells: implications in tumorigenesis and metastasis. J Cell Physiol. 2009; 222(2):268-77. DOI: 10.1002/jcp.21940. View