Design Principles in Mechanically Adaptable Biomaterials for Repairing Annulus Fibrosus Rupture: A Review

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2023 Sep 11

PMID 37692911

Authors

Dan Zhou

Hongmei Liu

Zhaomin Zheng

Decheng Wu

Affiliations

Soon will be listed here.

Abstract

Annulus fibrosus (AF) plays a crucial role in the biomechanical loading of intervertebral disc (IVD). AF is difficult to self-heal when the annulus tears develop, because AF has a unique intricate structure and biologic milieu . Tissue engineering is promising for repairing AF rupture, but construction of suitable mechanical matching devices or scaffolds is still a grand challenge. To deeply know the varied forces involved in the movement of the native annulus is highly beneficial for designing biomimetic scaffolds to recreate the AF function. In this review, we overview six freedom degrees of forces and adhesion strength on AF tissue. Then, we summarize the mechanical modalities to simulate related forces on AF and to assess the characteristics of biomaterials. We finally outline some current advanced techniques to develop mechanically adaptable biomaterials for AF rupture repair.

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