Obesity and Selected Allergic and Immunological Diseases-Etiopathogenesis, Course and Management

Overview

Journal Nutrients

Date 2023 Sep 9

PMID 37686844

Authors

Bartlomiej Morag

Patrycja Kozubek

Krzysztof Gomulka

Affiliations

Soon will be listed here.

Abstract

Obesity is a global problem. It affects every age group and is associated with many negative health effects. As an example, there is a relationship between obesity and allergic and immunological diseases, such as asthma, psoriasis, food allergies, allergic rhinitis and atopic dermatitis. Obesity undeniably affects their development. In addition, it causes adverse changes in the course and response to therapy in relation to patients without excessive body weight. The treatment of diseases associated with obesity is difficult; drugs are less effective and must be used in higher doses, and their use in patients with obesity is often associated with higher risks. The main form of treatment of all obesity-related diseases is a change in eating habits and increased physical activity, which leads to a decrease in body fat mass. The positive effect of reducing BMI has been confirmed in many independent studies. This paper reviews various types of research documents published since 2019. It aims to systematize the latest knowledge and highlight the need for further research for effective and sustainable treatment options for obesity, its complications and obesity-related diseases.

Citing Articles

Weight-Adjusted Waist Index, Psoriasis, and All-Cause Mortality: Findings from the NHANES 2003-2006 and 2009-2014.

Zhou T, Wu J, Wang Y, Gao Y, Cheng K Clin Cosmet Investig Dermatol. 2025; 18():7-18.

PMID: 39781099 PMC: 11708201. DOI: 10.2147/CCID.S497128.

Maternal influences on offspring food allergy.

Lee H, Nazmul T, Lan J, Oyoshi M Immunol Rev. 2024; 326(1):130-150.

PMID: 39275992 PMC: 11867100. DOI: 10.1111/imr.13392.

Associations of the planetary health diet index (PHDI) with asthma: the mediating role of body mass index.

Huang S, He Q, Wang X, Choi S, Gong H BMC Public Health. 2024; 24(1):2305.

PMID: 39187832 PMC: 11346270. DOI: 10.1186/s12889-024-19856-1.

Exploring the Complex Interplay of Obesity, Allergic Diseases, and Sleep-Disordered Breathing in Children.

Voltan C, Concer F, Pecoraro L, Pietrobelli A, Piacentini G, Zaffanello M Children (Basel). 2024; 11(5).

PMID: 38790590 PMC: 11120164. DOI: 10.3390/children11050595.

Effect of the gut microbiome, plasma metabolome, peripheral cells, and inflammatory cytokines on obesity: a bidirectional two-sample Mendelian randomization study and mediation analysis.

Li Y, Wang X, Zhang Z, Shi L, Cheng L, Zhang X Front Immunol. 2024; 15:1348347.

PMID: 38558794 PMC: 10981273. DOI: 10.3389/fimmu.2024.1348347.

References

Lang J . Obesity and childhood asthma. Curr Opin Pulm Med. 2018; 25(1):34-43. DOI: 10.1097/MCP.0000000000000537. View

Lang J . Contribution of comorbidities to obesity-related asthma in children. Paediatr Respir Rev. 2020; 37:22-29. DOI: 10.1016/j.prrv.2020.07.006. View

Muzumdar S, Rothe M . Nutrition and psoriasis. Clin Dermatol. 2022; 40(2):128-134. DOI: 10.1016/j.clindermatol.2021.10.005. View

Han M, Kim S, Oh I, Kim Y, Lee J . Obesity Can Contribute to Severe Persistent Allergic Rhinitis in Children through Leptin and Interleukin-1β. Int Arch Allergy Immunol. 2021; 182(6):546-552. DOI: 10.1159/000512920. View

Guo Z, Yang Y, Liao Y, Shi Y, Zhang L . Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity. JID Innov. 2022; 2(1):100064. PMC: 8659781. DOI: 10.1016/j.xjidi.2021.100064. View

Chen L, Collado K, Rastogi D . Contribution of systemic and airway immune responses to pediatric obesity-related asthma. Paediatr Respir Rev. 2020; 37:3-9. PMC: 8477371. DOI: 10.1016/j.prrv.2020.02.005. View

Kaushik S, Lebwohl M . Psoriasis: Which therapy for which patient: Psoriasis comorbidities and preferred systemic agents. J Am Acad Dermatol. 2018; 80(1):27-40. DOI: 10.1016/j.jaad.2018.06.057. View

Zhu Z, Guo Y, Shi H, Liu C, Panganiban R, Chung W . Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank. J Allergy Clin Immunol. 2019; 145(2):537-549. PMC: 7010560. DOI: 10.1016/j.jaci.2019.09.035. View

Rastogi D . Pediatric obesity-related asthma: A prototype of pediatric severe non-T2 asthma. Pediatr Pulmonol. 2020; 55(3):809-817. PMC: 7694442. DOI: 10.1002/ppul.24600. View

10.

Davis D, Drucker A, Alikhan A, Bercovitch L, Cohen D, Darr J . American Academy of Dermatology Guidelines: Awareness of comorbidities associated with atopic dermatitis in adults. J Am Acad Dermatol. 2022; 86(6):1335-1336.e18. DOI: 10.1016/j.jaad.2022.01.009. View

11.

Barros G, Duran P, Vera I, Bermudez V . Exploring the Links between Obesity and Psoriasis: A Comprehensive Review. Int J Mol Sci. 2022; 23(14). PMC: 9321445. DOI: 10.3390/ijms23147499. View

12.

Garcia-Rio F, Alvarez-Puebla M, Esteban-Gorgojo I, Barranco P, Olaguibel J . Obesity and Asthma: Key Clinical Questions. J Investig Allergol Clin Immunol. 2018; 29(4):262-271. DOI: 10.18176/jiaci.0316. View

13.

Jiang D, Wang L, Bai C, Chen O . Association between abdominal obesity and asthma: a meta-analysis. Allergy Asthma Clin Immunol. 2019; 15:16. PMC: 6431003. DOI: 10.1186/s13223-019-0333-6. View

14.

Vehapoglu A, Cakin Z, Kahraman F, Nursoy M, Toprak A . Is overweight/obesity a risk factor for atopic allergic disease in prepubertal children? A case-control study. J Pediatr Endocrinol Metab. 2021; 34(6):727-732. DOI: 10.1515/jpem-2021-0051. View

15.

Guerrero S, Panettieri Jr R, Rastogi D . Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma. Paediatr Drugs. 2023; 25(3):283-299. PMC: 11071627. DOI: 10.1007/s40272-022-00554-7. View

16.

Guo X, Cheng L, Yang S, Che H . Pro-inflammatory immunological effects of adipose tissue and risk of food allergy in obesity: Focus on immunological mechanisms. Allergol Immunopathol (Madr). 2019; 48(3):306-312. DOI: 10.1016/j.aller.2019.06.004. View

17.

Kunz M, Simon J, Saalbach A . Psoriasis: Obesity and Fatty Acids. Front Immunol. 2019; 10:1807. PMC: 6684944. DOI: 10.3389/fimmu.2019.01807. View

18.

Bantula M, Roca-Ferrer J, Arismendi E, Picado C . Asthma and Obesity: Two Diseases on the Rise and Bridged by Inflammation. J Clin Med. 2021; 10(2). PMC: 7825135. DOI: 10.3390/jcm10020169. View

19.

Darlenski R, Mihaylova V, Handjieva-Darlenska T . The Link Between Obesity and the Skin. Front Nutr. 2022; 9:855573. PMC: 8965625. DOI: 10.3389/fnut.2022.855573. View

20.

Zafiriou E, Daponte A, Siokas V, Tsigalou C, Dardiotis E, Bogdanos D . Depression and Obesity in Patients With Psoriasis and Psoriatic Arthritis: Is IL-17-Mediated Immune Dysregulation the Connecting Link?. Front Immunol. 2021; 12:699848. PMC: 8334867. DOI: 10.3389/fimmu.2021.699848. View