Electroanatomical Conduction Characteristics of Pig Myocardial Tissue Derived from High-Density Mapping

Overview

Journal J Clin Med

Specialty General Medicine

Date 2023 Sep 9

PMID 37685665

Authors

Theresa Isabelle Wilhelm

Thorsten Lewalter

Johannes Fischer

Judith Reiser

Julia Werner

Christine Baumgartner

Lukas Gleirscher

Petra Hoppmann

Christian Kupatt

Klaus Tiemann

Clemens Jilek

Affiliations

Soon will be listed here.

Abstract

Background: Ultra-high-density mapping systems allow more precise measurement of the heart chambers at corresponding conduction velocities (CVs) and voltage amplitudes (VAs). Our aim for this study was to define and compare a basic value set for unipolar CV and VA in all four heart chambers and their separate walls in healthy, juvenile porcine hearts using ultra-high-density mapping.

Methods: We used the Rhythmia Mapping System to create electroanatomical maps of four pig hearts in sinus rhythm. CVs and VAs were calculated for chambers and wall segments with overlapping circular areas (radius of 5 mm).

Results: We analysed 21 maps with a resolution of 1.4 points/mm. CVs were highest in the left atrium (LA), followed by the left ventricle (LV), right ventricle (RV), and right atrium (RA). As for VA, LV was highest, followed by RV, LA, and RA. The left chambers had a higher overall CV and VA than the right. Within the chambers, CV varied more in the right than in the left chambers, and VA varied in the ventricles but not in the atria. There was a slightly positive correlation between CVs and VAs at velocity values of <1.5 m/s.

Conclusions: In healthy porcine hearts, the left chambers showed higher VAs and CVs than the right. CV differs mainly within the right chambers and VA differs only within the ventricles. A slightly positive linear correlation was found between slow CVs and low VAs.

Citing Articles

Influence of Heart Rate and Change in Wavefront Direction through Pacing on Conduction Velocity and Voltage Amplitude in a Porcine Model: A High-Density Mapping Study.

Wilhelm T, Lewalter T, Reiser J, Werner J, Keil A, Oesterlein T J Pers Med. 2024; 14(5).

PMID: 38793055 PMC: 11122149. DOI: 10.3390/jpm14050473.

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