» Articles » PMID: 37681821

Achilles Tendinopathy Pathogenesis and Management: A Narrative Review

Overview
Publisher MDPI
Date 2023 Sep 8
PMID 37681821
Authors
Affiliations
Soon will be listed here.
Abstract

The Achilles tendon is the thickest and strongest tendon of the human body, and it is frequently injured during sports activity. The incidence of Achilles tendon pathologies has increased over recent decades, especially in the last few years, because of increased sports participation among the general population and due to the diffusion of competitive sports at a high level. Tendinopathies are common in athletes and in middle-aged overweight patients. The term "tendinopathy" refers to a condition characterised clinically by pain and swelling, with functional limitations of tendon and nearby structures, and consequently to chronic failure of healing response process. Tendinopathies can produce marked morbidity, and at present, scientifically validated management modalities are limited. Despite the constantly increasing interest and number of studies about Achilles tendinopathy (AT), there is still not a consensual point of view on which is the best treatment, and its management is still controversial. AT can be treated conservatively primarily, with acceptable results and clinical outcomes. When this approach fails, surgery should be considered. Several surgical procedures have been described for both conditions with a relatively high rate of success with few complications and the decision for treatment in patients with AT should be tailored on patient's needs and level of activity. The aim of this article is to give insights about the pathogenesis and most used and recent treatment options for AT.

Citing Articles

Changes in Tendon Thickness After Chondrovita FIT Supplementation in Elite Skaters: Findings from a Quasi-Experimental Study.

Giannini S, Amatori S, Vetrano M, Battistelli M, Belli A, Musicco G Int J Environ Res Public Health. 2025; 22(1).

PMID: 39857478 PMC: 11764826. DOI: 10.3390/ijerph22010024.


Treatment options for Achilles tendinopathy: a scoping review of preclinical studies.

Agyeman-Prempeh N, Maas H, Burchell G, Millar N, Moen M, Smit T PeerJ. 2025; 13():e18143.

PMID: 39807157 PMC: 11727660. DOI: 10.7717/peerj.18143.


The combination of hyaluronic acids and collagen boosts human Achilles tendon-derived cell escape from inflammation and matrix remodeling in vitro.

Mencarelli N, Arena D, Salamone M, Pietrangelo L, Berardi A, Cataldi A Inflamm Res. 2025; 74(1):4.

PMID: 39762639 DOI: 10.1007/s00011-024-01975-5.


Moderate- and High-Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon.

Tamburro M, Bonilla K, Shetye S, Leahy T, Eekhoff J, Kim M J Orthop Res. 2024; 43(3):519-530.

PMID: 39731286 PMC: 11806652. DOI: 10.1002/jor.26030.


The Fragility of Statistically Significant Binary Outcomes for Treating Achilles Tendinopathy: A Systematic Review of Randomized Trials.

Anaspure O, Patel S, Baumann A, Newsom A, Anastasio A, Amendola A Foot Ankle Orthop. 2024; 9(4):24730114241300160.

PMID: 39575398 PMC: 11580056. DOI: 10.1177/24730114241300160.


References
1.
de Vos R, Weir A, van Schie H, Bierma-Zeinstra S, Verhaar J, Weinans H . Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. JAMA. 2010; 303(2):144-9. DOI: 10.1001/jama.2009.1986. View

2.
Maffulli N, Binfield P, Moore D, King J . Surgical decompression of chronic central core lesions of the Achilles tendon. Am J Sports Med. 1999; 27(6):747-52. DOI: 10.1177/03635465990270061101. View

3.
Testa V, Capasso G, Benazzo F, Maffulli N . Management of Achilles tendinopathy by ultrasound-guided percutaneous tenotomy. Med Sci Sports Exerc. 2002; 34(4):573-80. DOI: 10.1097/00005768-200204000-00002. View

4.
Longo U, Ramamurthy C, Denaro V, Maffulli N . Minimally invasive stripping for chronic Achilles tendinopathy. Disabil Rehabil. 2008; 30(20-22):1709-13. DOI: 10.1080/09638280701786922. View

5.
Nazim B Tengku Yusof T, Seow D, Vig K . Extracorporeal Shockwave Therapy for Foot and Ankle Disorders: A Systematic Review and Meta-Analysis. J Am Podiatr Med Assoc. 2021; 112(3). DOI: 10.7547/18-191. View