Case Report: Missing Zinc Finger Domains: Hemophagocytic Lymphohistiocytosis in a GATA2 Deficiency Patient Triggered by Non-tuberculous Mycobacteriosis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2023 Sep 8

PMID 37680631

Authors

Xin Huang

Bingxuan Wu

Di Wu

Xiaoming Huang

Min Shen

Affiliations

Soon will be listed here.

Abstract

Haploinsufficiency of GATA2, also known as GATA2 deficiency, leads to a wide spectrum of clinical manifestations. Here we described another 28-year-old man with a GATA2 variant who also suffered from hemophagocytic lymphohistiocytosis(HLH), who was finally diagnosed with HLH triggered by bloodstream infection due to primary immunodeficiency. We reviewed GATA2 deficiency patients with HLH and found that GATA2 variants causing loss of zinc finger domains were associated with HLH, and erythema nodosa might be an accompanying symptom.

Citing Articles

GATA2 deficiency and hemophagocytic lymphohistiocytosis (HLH): a systematic review of reported cases.

Rezaei Zadeh Rukerd M, Mirkamali H, Nakhaie M, Alizadeh S BMC Infect Dis. 2024; 24(1):1239.

PMID: 39497062 PMC: 11536883. DOI: 10.1186/s12879-024-10145-1.

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