Exercise Training Attenuates Skeletal Muscle Fat Infiltration and Improves Insulin Pathway of Patients with Immune-mediated Necrotizing Myopathies and Dermatomyositis

Overview

Journal Arch Rheumatol

Specialty Rheumatology

Date 2023 Sep 8

PMID 37680507

Authors

Diego Sales de Oliveira

Isabela Bruna Pires Borges

Suely Kazue Nagahashi Marie

Antonio Marcondes Lerario

Sueli Mieko Oba-Shinjo

Samuel Katsuyuki Shinjo

Affiliations

Soon will be listed here.

Abstract

Objectives: This study aims to evaluate the effects of exercise training on intramuscular lipid content and genes related to insulin pathway in patients with systemic autoimmune myopathies (SAMs).

Patients And Methods: Between January 2016 and May 2019, a total of seven patients with dermatomyositis (DM; 3 males, 4 females; mean age: 49.8±2.3 years; range, 43 to 54 years), six with immune mediated necrotizing myopathy (IMNM; 3 males, 3 females; mean age: 58.5±10.6 years; range, 46 to 74 years), and 10 control individuals (CTRL group; 4 males, 6 females; mean age: 48.7±3.9 years; range, 41 to 56 years) were included. The muscle biopsy before and after the intervention was performed to evaluate the intramuscular lipid content. Patients underwent a combined exercise training program for 12 weeks. Skeletal muscle gene expression was analyzed and the DM versus CTRL group, DM pre- and post-, and IMNM pre- and post-intervention were compared.

Results: The DM group had a higher intramuscular lipid content in type II muscle fibers compared to the CTRL group. After the intervention, there was a reduction of lipid content in type I and II fibers in DM and IMNM group. The CTRL group showed a significantly higher expression of genes related to insulin and lipid oxidation pathways (, and ) compared to the DM group. After exercise training, there was an increase gene expression related to insulin pathway and lipid oxidation in DM group (, and ) and in IMNM group (, and ).

Conclusion: Exercise training attenuated the amount of fat in type I and II muscle fibers in patients with DM and IMNM and increased gene expression related to insulin pathways and lipid oxidation in DM and IMNM. These results suggest that exercise training can improve the quality and metabolic functions of skeletal muscle in these diseases.

Citing Articles

Skeletal muscle disorders as risk factors for type 2 diabetes.

Tammineni E, Manno C, Oza G, Figueroa L Mol Cell Endocrinol. 2025; 599:112466.

PMID: 39848431 PMC: 11886953. DOI: 10.1016/j.mce.2025.112466.

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