Significance of Connective Tissue Proliferation in the Breakdown of Cartilage: a Novel in Vivo Model

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1986 Sep 1

PMID 3767463

Citations 4

Authors

F B De Brito

A R Moore

S Adhya

A Y Al-Duaij

D A Willoughby

Affiliations

Soon will be listed here.

Abstract

The implantation of homologous femoral head cartilage in subcutaneous tissues of random bred Wistar rats results in both subchondral and articular surfaces becoming overlaid by an adherent granulation tissue comprising predominantly fibroblast-like cells. The response of the tissue to cartilage encapsulated with cotton fibres was also similar but erosions, mainly subchondral, were more evident and proteoglycan loss markedly greater. The connective tissue response to cotton was the progressive formation of a foreign body granuloma comprising mononuclear cells, multinucleated giant cells, and fibroblasts with very few polymorphonuclear leucocytes.

Citing Articles

Professor Derek Albert Willoughby (1930-2004).

Rainsford K Inflammopharmacology. 2005; 12(5-6):407-39.

PMID: 16259705 DOI: 10.1163/156856005774382779.

Cartilage damage by a granulomatous reaction in a murine species.

De Brito F, Moore A, Holmes M, Willoughby D Br J Exp Pathol. 1987; 68(5):675-86.

PMID: 3689670 PMC: 2013187.

Drug effects on a novel model of connective tissue breakdown.

De Brito F, Holmes M, Carney S, Willoughby D Agents Actions. 1987; 21(3-4):287-9.

PMID: 3687583 DOI: 10.1007/BF01966493.

Oestrogens, joint disease, and cartilage.

Chander C, Spector T Ann Rheum Dis. 1991; 50(3):139-40.

PMID: 2015006 PMC: 1004359. DOI: 10.1136/ard.50.3.139.

References

Zvaifler N . The immunopathology of joint inflammation in rheumatoid arthritis. Adv Immunol. 1973; 16(0):265-336. DOI: 10.1016/s0065-2776(08)60299-0. View

SWINGLE K, SHIDEMAN F . Phases of the inflammatory response to subcutaneous implantation of a cotton pellet and their modification by certain anti-inflammatory agents. J Pharmacol Exp Ther. 1972; 183(1):226-34. View

Vaes G, Hauser P . Lymphocyte-macrophage-fibroblast co-operation in the inflammatory degradation of cartilage and connective tissue. Agents Actions Suppl. 1980; 7:100-8. View

Edwards J, Sedgwick A, Willoughby D . The formation of a structure with the features of synovial lining by subcutaneous injection of air: an in vivo tissue culture system. J Pathol. 1981; 134(2):147-56. DOI: 10.1002/path.1711340205. View

Farndale R, Sayers C, Barrett A . A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connect Tissue Res. 1982; 9(4):247-8. DOI: 10.3109/03008208209160269. View

Shiozawa S, Shiozawa K, Fujita T . Morphologic observations in the early phase of the cartilage-pannus junction. Light and electron microscopic studies of active cellular pannus. Arthritis Rheum. 1983; 26(4):472-8. DOI: 10.1002/art.1780260404. View

Sedgwick A, Sin Y, Edwards J, Willoughby D . Increased inflammatory reactivity in newly formed lining tissue. J Pathol. 1983; 141(4):483-95. DOI: 10.1002/path.1711410406. View

Sin Y, Sedgwick A, Willoughby D . Studies on the mechanism of cartilage degradation. J Pathol. 1984; 142(1):23-30. DOI: 10.1002/path.1711420107. View

DINGLE J . The role of catabolin in the control of cartilage matrix integrity. J Rheumatol Suppl. 1983; 11:38-44. View

10.

Krane S, Amento E . Cellular interactions and control of collagenase secretion in the synovium. J Rheumatol Suppl. 1983; 11:7-12. View

11.

Saklatvala J, Pilsworth L, Sarsfield S, Gavrilovic J, Heath J . Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein. Biochem J. 1984; 224(2):461-6. PMC: 1144453. DOI: 10.1042/bj2240461. View

12.

OSullivan F, Fassbender H, Gay S, Koopman W . Etiopathogenesis of the rheumatoid arthritis-like disease in MRL/l mice. I. The histomorphologic basis of joint destruction. Arthritis Rheum. 1985; 28(5):529-36. DOI: 10.1002/art.1780280511. View

13.

Sedgwick A, Moore A, Al-Duaij A, Edwards J, Willoughby D . Studies into the influence of carrageenan-induced inflammation on articular cartilage degradation using implantation into air pouches. Br J Exp Pathol. 1985; 66(4):445-53. PMC: 2041090. View

14.

Rainsford K . Effects of anti-inflammatory drugs on catabolin-induced cartilage destruction in vitro. Int J Tissue React. 1985; 7(2):123-6. View

15.

Meier R, SCHULER W, DESAULLES P . [On the mechanism of cortisone inhibition of connective tissue proliferation]. Experientia. 1950; 6(12):469-71. DOI: 10.1007/BF02154110. View

16.

Eichhorn J, SNIFFEN R . INFLUENCE OF CORTISOL AND INSULIN ON IN VITRO INCORPORATION OF AMINO ACIDS INTO PROTEIN OF GRANULOMA TISSUE. Endocrinology. 1964; 75:341-51. DOI: 10.1210/endo-75-3-341. View

17.

Freeman P, Mangan F, WATKINS D . Some effects of hydrocortisone on the early development of the rat cotton pellet granuloma. Biochem Pharmacol. 1979; 28(5):573-8. DOI: 10.1016/0006-2952(79)90137-0. View