» Articles » PMID: 37674385

Benefits of Soybean in the Era of Precision Medicine: A Review of Clinical Evidence

Overview
Date 2023 Sep 7
PMID 37674385
Authors
Affiliations
Soon will be listed here.
Abstract

Soybean () is an important ingredient of cuisines worldwide. While there is a wealth of evidence that soybean could be a good source of macronutrients and phytochemicals with health-promoting effects, concerns regarding adverse effects have been raised. In this work, we reviewed the current clinical evidence focusing on the benefits and risks of soybean ingredients. In breast, prostate, colorectal, ovarian, and lung cancer, epidemiological studies showed an inverse association between soybean food intake and cancer risks. Soybean intake was inversely correlated with risks of type 2 diabetes mellitus (T2DM), and soy isoflavones ameliorated osteoporosis and hot flashes. Notably, soybean was one of the dietary protein sources that may reduce the risk of breast cancer and T2DM. However, soybean had adverse effects on certain types of drug treatment and caused allergies. In sum, this work provides useful considerations for planning clinical soybean research and selecting dietary protein sources for human health.

Citing Articles

Dietary Patterns in Asia: Current Evidence and Future Directions.

Schwingshackl L, Hoffmann G Adv Nutr. 2024; 15(7):100250.

PMID: 39009488 PMC: 11294744. DOI: 10.1016/j.advnut.2024.100250.

References
1.
Liu Z, Chen Y, Ho S . Effects of soy intake on glycemic control: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2011; 93(5):1092-101. DOI: 10.3945/ajcn.110.007187. View

2.
Messina M . Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature. Nutrients. 2016; 8(12). PMC: 5188409. DOI: 10.3390/nu8120754. View

3.
Eastell R, Szulc P . Use of bone turnover markers in postmenopausal osteoporosis. Lancet Diabetes Endocrinol. 2017; 5(11):908-923. DOI: 10.1016/S2213-8587(17)30184-5. View

4.
Liu Z, Li W, Sun J, Liu C, Zeng Q, Huang J . Intake of soy foods and soy isoflavones by rural adult women in China. Asia Pac J Clin Nutr. 2004; 13(2):204-9. View

5.
Daily J, Ko B, Ryuk J, Liu M, Zhang W, Park S . Equol Decreases Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2018; 22(2):127-139. DOI: 10.1089/jmf.2018.4265. View