The Importance of "Negative" Results: Lipid Lessons in Coronavirus Biology

Overview

Journal Am J Respir Cell Mol Biol

Specialties Cell Biology
Molecular Biology

Date 2023 Sep 6

PMID 37672661

Authors

Sarah R Leist

Jason R Mock

Affiliations

Soon will be listed here.

References

Fessler M . The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease. Pharmacol Ther. 2017; 181:1-12. PMC: 5743771. DOI: 10.1016/j.pharmthera.2017.07.010. View

Heisler D, Johnson K, Ma D, Ohlson M, Zhang L, Tran M . A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection. Elife. 2023; 12. PMC: 9925056. DOI: 10.7554/eLife.83534. View

Leist S, Dinnon 3rd K, Schafer A, Tse L, Okuda K, Hou Y . A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice. Cell. 2020; 183(4):1070-1085.e12. PMC: 7510428. DOI: 10.1016/j.cell.2020.09.050. View

Brown M, Radhakrishnan A, Goldstein J . Retrospective on Cholesterol Homeostasis: The Central Role of Scap. Annu Rev Biochem. 2017; 87:783-807. PMC: 5828883. DOI: 10.1146/annurev-biochem-062917-011852. View

Wang S, Li W, Hui H, Tiwari S, Zhang Q, Croker B . Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol. EMBO J. 2020; 39(21):e106057. PMC: 7537045. DOI: 10.15252/embj.2020106057. View

Crimi E, Rumana U, Ang D, Cintron C, Kapisoda K, Zeleznak W . Beneficial effects of prehospital use of statins in a large United States cohort of hospitalized coronavirus disease 2019 patients. J Cardiovasc Med (Hagerstown). 2023; 24(3):172-183. PMC: 9912995. DOI: 10.2459/JCM.0000000000001441. View

Brown M, Goldstein J . Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol. J Biol Chem. 1974; 249(22):7306-14. View

Fessler M, Madenspacher J, Baker P, Hilligan K, Bohrer A, Castro E . Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Mice. Am J Respir Cell Mol Biol. 2023; 69(6):638-648. PMC: 10704115. DOI: 10.1165/rcmb.2023-0007OC. View

Liu S, Aliyari R, Chikere K, Li G, Marsden M, Smith J . Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. Immunity. 2013; 38(1):92-105. PMC: 3698975. DOI: 10.1016/j.immuni.2012.11.005. View

10.

Madenspacher J, Morrell E, Gowdy K, McDonald J, Thompson B, Muse G . Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation. JCI Insight. 2020; 5(11). PMC: 7308063. DOI: 10.1172/jci.insight.137189. View

11.

Cyster J, Dang E, Reboldi A, Yi T . 25-Hydroxycholesterols in innate and adaptive immunity. Nat Rev Immunol. 2014; 14(11):731-43. DOI: 10.1038/nri3755. View

12.

Zinellu A, Paliogiannis P, Fois A, Solidoro P, Carru C, Mangoni A . Cholesterol and Triglyceride Concentrations, COVID-19 Severity, and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression. Front Public Health. 2021; 9:705916. PMC: 8417431. DOI: 10.3389/fpubh.2021.705916. View

13.

Calfee C, Delucchi K, Sinha P, Matthay M, Hackett J, Shankar-Hari M . Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med. 2018; 6(9):691-698. PMC: 6201750. DOI: 10.1016/S2213-2600(18)30177-2. View

14.

de Freitas F, Levy D, Reichert C, Cunha-Neto E, Kalil J, Bydlowski S . Effects of Oxysterols on Immune Cells and Related Diseases. Cells. 2022; 11(8). PMC: 9031443. DOI: 10.3390/cells11081251. View

15.

Heng T, Painter M . The Immunological Genome Project: networks of gene expression in immune cells. Nat Immunol. 2008; 9(10):1091-4. DOI: 10.1038/ni1008-1091. View

16.

Lund E, Kerr T, Sakai J, Li W, Russell D . cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. J Biol Chem. 1998; 273(51):34316-27. DOI: 10.1074/jbc.273.51.34316. View