Declined Live Birth Rate from in Vitro Fertilization Fresh Cycles Performed During Chinese New Year Holiday Season

Overview

Journal Risk Manag Healthc Policy

Publisher Dove Medical Press

Specialty Public Health

Date 2023 Sep 6

PMID 37670732

Authors

Jiajia Zhai

Junyan Zhang

Jingfang He

Guanqun Li

Guimin Hao

Affiliations

Soon will be listed here.

Abstract

Purpose: This study aims to investigate the impact of the Chinese New Year (CNY) holiday season on the outcomes of In Vitro Fertilization (IVF) fresh embryo transfer cycles.

Participants And Methods: This retrospective study analyzed 4688 patients who received their first IVF fresh cycle attempt between January 2017 and October 2021. Of these, 4449 women underwent IVF during non-holiday seasons, while 239 women were treated during the CNY holiday season. The study included women who underwent IVF treatment during the specified time frame. The primary outcome was the live birth rate (LBR).

Results: The study found that the LBR of IVF performed during the CNY holiday season was 32.22%, which is significantly lower than that of the non-holiday season (43.38%, p<0.001). Multivariate logistic regression analysis showed that the CNY holiday season (OR=0.62, 95% CI 0.47-0.82, p=0.001) was an independent factor associated with the live birth rate. Propensity score matching (PSM) data analysis showed that the LBR in the CNY holiday season group was 31.78% compared to 42.64% in the non-holiday season group (p=0.005). Inverse probability of treatment weighting (IPTW) data also indicated that the CNY holiday season had a lower LBR than the non-holiday season (OR=0.64, 95% CI 0.47-0.87, p=0.005).

Conclusion: IVF performed during the CNY holiday season results in a lower live birth rate, potentially indicating that certain lifestyle adjustments during this period, such as unhealthy dietary, tobacco and alcohol usage, sleep disruption, and emotional stress experienced could have some influence on the outcomes.

References

Correia K, Farland L, Missmer S, Racowsky C . The association between season, day length, and temperature on clinical outcomes after cryopreserved embryo transfer. Fertil Steril. 2021; 117(3):539-547. DOI: 10.1016/j.fertnstert.2021.11.014. View

Vittinghoff E, McCulloch C . Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol. 2006; 165(6):710-8. DOI: 10.1093/aje/kwk052. View

Helander E, Wansink B, Chieh A . Weight Gain over the Holidays in Three Countries. N Engl J Med. 2016; 375(12):1200-2. DOI: 10.1056/NEJMc1602012. View

Rubes J, Lowe X, Moore 2nd D, Perreault S, Slott V, Evenson D . Smoking cigarettes is associated with increased sperm disomy in teenage men. Fertil Steril. 1998; 70(4):715-23. DOI: 10.1016/s0015-0282(98)00261-1. View

Klonoff-Cohen H, Lam-Kruglick P, Gonzalez C . Effects of maternal and paternal alcohol consumption on the success rates of in vitro fertilization and gamete intrafallopian transfer. Fertil Steril. 2003; 79(2):330-9. DOI: 10.1016/s0015-0282(02)04582-x. View

Harrell Jr F, Lee K, Mark D . Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med. 1996; 15(4):361-87. DOI: 10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4. View

Gaskins A, Nassan F, Chiu Y, Arvizu M, Williams P, Keller M . Dietary patterns and outcomes of assisted reproduction. Am J Obstet Gynecol. 2019; 220(6):567.e1-567.e18. PMC: 6545142. DOI: 10.1016/j.ajog.2019.02.004. View

Caetano G, Bozinovic I, Dupont C, Leger D, Levy R, Sermondade N . Impact of sleep on female and male reproductive functions: a systematic review. Fertil Steril. 2020; 115(3):715-731. DOI: 10.1016/j.fertnstert.2020.08.1429. View

Ravisankar S, Ting A, Murphy M, Redmayne N, Wang D, McArthur C . Short-term Western-style diet negatively impacts reproductive outcomes in primates. JCI Insight. 2021; 6(4). PMC: 7934943. DOI: 10.1172/jci.insight.138312. View

10.

Hughes E, Younglai E, Ward S . Cigarette smoking and outcomes of in-vitro fertilization and embryo transfer: a prospective cohort study. Hum Reprod. 1992; 7(3):358-61. DOI: 10.1093/oxfordjournals.humrep.a137650. View

11.

Snowden J, Caughey A . Is there a weekend effect in obstetrics?. BMJ. 2015; 351:h6192. DOI: 10.1136/bmj.h6192. View

12.

Rich Z, Hu M, Xiao S . Gifting and sharing cigarettes in a rural Chinese village: a cross-sectional study. Tob Control. 2013; 23(6):496-500. DOI: 10.1136/tobaccocontrol-2012-050956. View

13.

Hviid A, Laksafoss A, Hedley P, Lausten-Thomsen U, Hjalgrim H, Christiansen M . Assessment of Seasonality and Extremely Preterm Birth in Denmark. JAMA Netw Open. 2022; 5(2):e2145800. PMC: 8814911. DOI: 10.1001/jamanetworkopen.2021.45800. View

14.

Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y . Transfer of Fresh versus Frozen Embryos in Ovulatory Women. N Engl J Med. 2018; 378(2):126-136. DOI: 10.1056/NEJMoa1705334. View

15.

Dechanet C, Brunet C, Anahory T, Hamamah S, Hedon B, Dechaud H . [Effects of cigarette smoking on female reproduction: from oocyte to embryo (Part I)]. Gynecol Obstet Fertil. 2011; 39(10):559-66. DOI: 10.1016/j.gyobfe.2011.07.033. View

16.

Joesbury K, Edirisinghe W, Phillips M, Yovich J . Evidence that male smoking affects the likelihood of a pregnancy following IVF treatment: application of the modified cumulative embryo score. Hum Reprod. 1998; 13(6):1506-13. DOI: 10.1093/humrep/13.6.1506. View

17.

Klonoff-Cohen H, Natarajan L . The concerns during assisted reproductive technologies (CART) scale and pregnancy outcomes. Fertil Steril. 2004; 81(4):982-8. DOI: 10.1016/j.fertnstert.2003.08.050. View

18.

Crean A, Senior A . High-fat diets reduce male reproductive success in animal models: A systematic review and meta-analysis. Obes Rev. 2019; 20(6):921-933. DOI: 10.1111/obr.12827. View

19.

Maroufizadeh S, Omani-Samani R, Almasi-Hashiani A, Amini P, Sepidarkish M . The reliability and validity of the Patient Health Questionnaire-9 (PHQ-9) and PHQ-2 in patients with infertility. Reprod Health. 2019; 16(1):137. PMC: 6734346. DOI: 10.1186/s12978-019-0802-x. View

20.

Klonoff-Cohen H . Female and male lifestyle habits and IVF: what is known and unknown. Hum Reprod Update. 2005; 11(2):179-203. DOI: 10.1093/humupd/dmh059. View