RAIDS Atlas of Significant Genetic and Protein Biomarkers in Cervical Cancer

Overview

Journal J Gynecol Oncol

Specialties Gynecology & Obstetrics
Oncology

Date 2023 Sep 5

PMID 37668079

Authors

Suzy Scholl

Diana Bello Roufai

Linda Larbi Cherif

Maud Kamal

Affiliations

Soon will be listed here.

Abstract

Loss of function in epigenetic acting genes together with driver alterations in the PIK3CA pathway have been shown significantly associated with poor outcome in cervical squamous cell cancer. More recently, a CoxBoost analysis identified 16 gene alterations and 30 high level activated proteins to be of high interest, due to their association with either good or bad outcome, in the context of treatment received by chemoradiation. The objectives here were to review and confirm the significance of these molecular alterations as suggested by literature reports and to pinpoint alternate treatments options for poor-responders to chemoradiation.

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References

Maurer U, Charvet C, Wagman A, Dejardin E, Green D . Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell. 2006; 21(6):749-60. DOI: 10.1016/j.molcel.2006.02.009. View

Zhu S, Bjorge J, Fujita D . PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation. Cancer Res. 2007; 67(21):10129-37. DOI: 10.1158/0008-5472.CAN-06-4338. View

Bumrungthai S, Munjal K, Nandekar S, Cooper K, Ekalaksananan T, Pientong C . Epidermal growth factor receptor pathway mutation and expression profiles in cervical squamous cell carcinoma: therapeutic implications. J Transl Med. 2015; 13:244. PMC: 4513684. DOI: 10.1186/s12967-015-0611-0. View

Perdrix A, Najem A, Saussez S, Awada A, Journe F, Ghanem G . PRIMA-1 and PRIMA-1 (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies. Cancers (Basel). 2017; 9(12). PMC: 5742820. DOI: 10.3390/cancers9120172. View

Scholl S, Popovic M, De la Rochefordiere A, Girard E, Dureau S, Mandic A . Clinical and genetic landscape of treatment naive cervical cancer: Alterations in PIK3CA and in epigenetic modulators associated with sub-optimal outcome. EBioMedicine. 2019; 43:253-260. PMC: 6562019. DOI: 10.1016/j.ebiom.2019.03.069. View

Noh H, Zhao Q, Yan J, Kong L, Gabrusiewicz K, Hong S . Cell surface vimentin-targeted monoclonal antibody 86C increases sensitivity to temozolomide in glioma stem cells. Cancer Lett. 2018; 433:176-185. PMC: 6086585. DOI: 10.1016/j.canlet.2018.07.008. View

Dong B, Jaeger A, Hughes P, Loiselle D, Hauck J, Fu Y . Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1. Sci Transl Med. 2020; 12(574). PMC: 10571035. DOI: 10.1126/scitranslmed.abb5647. View

Kolijn K, Verhoef E, Smid M, Bottcher R, Jenster G, Debets R . Epithelial-Mesenchymal Transition in Human Prostate Cancer Demonstrates Enhanced Immune Evasion Marked by IDO1 Expression. Cancer Res. 2018; 78(16):4671-4679. DOI: 10.1158/0008-5472.CAN-17-3752. View

Ryazanov A, Shestakova E, Natapov P . Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation. Nature. 1988; 334(6178):170-3. DOI: 10.1038/334170a0. View

10.

Takahashi S, Fujiwara Y, Nakano K, Shimizu T, Tomomatsu J, Koyama T . Safety and pharmacokinetics of milademetan, a MDM2 inhibitor, in Japanese patients with solid tumors: A phase I study. Cancer Sci. 2021; 112(6):2361-2370. PMC: 8177775. DOI: 10.1111/cas.14875. View

11.

Fiorentino F, Marchesi I, Schroder C, Schmidt R, Yokota J, Bagella L . BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells. Int J Mol Sci. 2020; 21(24). PMC: 7766292. DOI: 10.3390/ijms21249595. View

12.

Terzic T, Mills A, Zadeh S, Atkins K, Hanley K . GATA3 Expression in Common Gynecologic Carcinomas: A Potential Pitfall. Int J Gynecol Pathol. 2018; 38(5):485-492. DOI: 10.1097/PGP.0000000000000541. View

13.

Wiese M, Walther N, Diederichs C, Schill F, Monecke S, Salinas G . The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner. Oncotarget. 2017; 8(16):27300-27313. PMC: 5432336. DOI: 10.18632/oncotarget.15934. View

14.

Henager S, Henriquez S, Dempsey D, Cole P . Analysis of Site-Specific Phosphorylation of PTEN by Using Enzyme-Catalyzed Expressed Protein Ligation. Chembiochem. 2019; 21(1-2):64-68. PMC: 7012368. DOI: 10.1002/cbic.201900316. View

15.

Rath G, Jawanjal P, Salhan S, Nalliah M, Dhawan I . Clinical significance of inactivated glycogen synthase kinase 3β in HPV-associated cervical cancer: Relationship with Wnt/β-catenin pathway activation. Am J Reprod Immunol. 2014; 73(5):460-78. DOI: 10.1111/aji.12346. View

16.

. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015; 517(7536):576-82. PMC: 4311405. DOI: 10.1038/nature14129. View

17.

Scholl S, Beal J, De Koning L, Girard E, Popovic M, De la Rochefordiere A . Genetic markers and phosphoprotein forms of beta-catenin pβ-Cat552 and pβ-Cat675 are prognostic biomarkers of cervical cancer. EBioMedicine. 2020; 61:103049. PMC: 7581879. DOI: 10.1016/j.ebiom.2020.103049. View

18.

Morse M, Balogh K, Brendle S, Campbell C, Chen M, Furze R . BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo. Antiviral Res. 2018; 154:158-165. PMC: 5955851. DOI: 10.1016/j.antiviral.2018.03.012. View

19.

Lin Y, Meng F, Lu Z, Chen K, Tao Y, Ouyang Y . Knockdown of PKM2 suppresses tumor progression in human cervical cancer by modulating epithelial-mesenchymal transition via Wnt/β-catenin signaling. Cancer Manag Res. 2018; 10:4191-4202. PMC: 6177516. DOI: 10.2147/CMAR.S178219. View

20.

Conza D, Mirra P, Cali G, Insabato L, Fiory F, Beguinot F . Metformin Dysregulates the Unfolded Protein Response and the WNT/β-Catenin Pathway in Endometrial Cancer Cells through an AMPK-Independent Mechanism. Cells. 2021; 10(5). PMC: 8147131. DOI: 10.3390/cells10051067. View