Pathological Epigenetic Events and Reversibility review: the Intersection Between Hallmarks of Aging and Developmental Origin of Health and Disease

Overview

Journal Epigenomics

Specialty Genetics

Date 2023 Sep 5

PMID 37667910

Authors

Douglas M Ruden

Aditi Singh

Daniel A Rappolee

Affiliations

Soon will be listed here.

Abstract

We discuss pathological epigenetic events that are reversible (PEERs). A recent study by Poganik and colleagues showed that severe stress in mice and humans transiently elevates biological age of several tissues, and this transient age increase is reversible when the stress is removed. These studies suggest new strategies for reversing normal aging. However, it is important to note that developmental origin of health and disease studies have shown that developmental exposure to toxic chemicals such as lead causes permanent changes in neuron shape, connectivity and cellular hyperplasia of organs such as the heart and liver. In this review, the PEER hypothesis speculates that the hallmarks of aging and the hallmarks of developmental origin of health and disease intersect at PEERs.

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