[Biomechanical Properties of Epithelial Mesenchymal Transition in Idiopathic Pulmonary Fibrosis]

Overview

Journal Sheng Wu Yi Xue Gong Cheng Xue Za Zhi

Specialty Biomedical Engineering

Date 2023 Sep 4

PMID 37666752

Authors

Mingyan Li

Meihao Sun

Yuanbo Jia

Hui Ren

Han Liu

Affiliations

Soon will be listed here.

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive scar-forming disease with a high mortality rate that has received widespread attention. Epithelial mesenchymal transition (EMT) is an important part of the pulmonary fibrosis process, and changes in the biomechanical properties of lung tissue have an important impact on it. In this paper, we summarize the changes in the biomechanical microenvironment of lung tissue in IPF-EMT in recent years, and provide a systematic review on the effects of alterations in the mechanical microenvironment in pulmonary fibrosis on the process of EMT, the effects of mechanical factors on the behavior of alveolar epithelial cells in EMT and the biomechanical signaling in EMT, in order to provide new references for the research on the prevention and treatment of IPF.

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