Improved Survival of SARS COV-2-infected K18- Mice Treated with Adenosine AR Agonist

Overview

Journal Heliyon

Specialty Social Sciences

Date 2023 Sep 4

PMID 37664715

Authors

Barbara J Mann

Preeti Chhabra

Mingyang Ma

Savannah G Brovero

Riley T Hannan

Jeffrey M Sturek

Marieke K Jones

Joel Linden

Kenneth L Brayman

Affiliations

Soon will be listed here.

Abstract

A life-threatening manifestation of Covid-19 infection is a cytokine storm that requires hospitalization and supplemental oxygen. Various strategies to reduce inflammatory cytokines have had some success in limiting cytokine storm and improving survival. Agonists of adenosine A receptors (AR) reduce cytokine release from most immune cells. Apadenoson is a potent and selective anti-inflammatory adenosine analog that reduces inflammation. When administered by subcutaneous osmotic pumps to mice infected with SARS CoV-2, Apadenoson was found to improve the outcomes of infection as measured by a decrease in weight loss, improved clinical symptoms, reduced levels of proinflammatory cytokines and chemokines in bronchial lavage (BAL) fluid, and enhanced survival of K18- transgenic mice. These results support further examination of AR agonists as therapies for treating cytokine storm due to COVID-19.

Citing Articles

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PMID: 39115571 DOI: 10.1007/s11033-024-09839-1.

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