The Paradoxical Association of Lipids with Survival and Walking Ability of Hip Fractures in Geriatric Patients After Surgery: A 1-Year Follow-Up Study

Overview

Journal Int J Gen Med

Publisher Dove Medical Press

Specialty General Medicine

Date 2023 Sep 4

PMID 37662501

Authors

Zhibang Zhao

Wenliang Fan

Liqiang Wang

Qingbo Chu

Affiliations

Soon will be listed here.

Abstract

Background: We aimed to explore the association between lipids and the survival and walking ability of hip fractures in geriatric patients after surgery.

Methods: Restricted cubic spline (RCS) was established to explore the nonlinear relationship between lipids and 1-year mortality of hip fractures, and the cut-off points were also determined by RCS. Then, the patients were divided into three groups: low, middle, and high levels of LDL-c. Then, the survival and walking ability of patients from different groups were compared, and the Cox regression and Logistics regression were used to identify the relationships between lipids and the survival and walking ability of hip fractures.

Results: The patients with middle levels of LDL-c had a significantly high survival probability than those with low or high levels of LDL-c (p < 0.001). The patients with low levels of LDL-c and with high levels of LDL-c may have a poor prognosis compared with patients with middle levels of LDL-c in 6-month mortality, 6-month free walking ability, 1-year mortality, and 1-year free walking ability (All p < 0.05).

Conclusion: Low and high levels of LDL-c may both relate to the poor survival and walking ability of hip fractures.

Citing Articles

Development and validation of risk prediction nomograms for acute respiratory failure in elderly patients with hip fracture.

Li Y, Dong B J Orthop Surg Res. 2023; 18(1):899.

PMID: 38007467 PMC: 10676597. DOI: 10.1186/s13018-023-04395-z.

References

Wang C, Xu B, Wang P, Yu W, Zeng X, Xiong N . Association of dyslipidemia with chronic non-malignant pain in elderly patients with femoral neck fractures treated by primary total hip arthroplasty: a retrospective study. J Int Med Res. 2021; 49(9):3000605211045224. PMC: 8489765. DOI: 10.1177/03000605211045224. View

Dwivedi A, Anggard E, Carrier M . Oxidized LDL-mediated monocyte adhesion to endothelial cells does not involve NFkappaB. Biochem Biophys Res Commun. 2001; 284(1):239-44. DOI: 10.1006/bbrc.2001.4955. View

Aude M, Jean-Jacques B, Laura I, Felicia B, Alexia C, Serge R . Fracture distribution in postmenopausal women: a FRISBEE sub-study. Arch Osteoporos. 2022; 18(1):3. DOI: 10.1007/s11657-022-01191-w. View

Penson P, Long D, Howard G, Toth P, Muntner P, Howard V . Associations between very low concentrations of low density lipoprotein cholesterol, high sensitivity C-reactive protein, and health outcomes in the Reasons for Geographical and Racial Differences in Stroke (REGARDS) study. Eur Heart J. 2018; 39(40):3641-3653. PMC: 6195947. DOI: 10.1093/eurheartj/ehy533. View

Wang B, Liu J, Chen S, Ying M, Chen G, Liu L . Malnutrition affects cholesterol paradox in coronary artery disease: a 41,229 Chinese cohort study. Lipids Health Dis. 2021; 20(1):36. PMC: 8056540. DOI: 10.1186/s12944-021-01460-6. View

Xie R, Huang X, Zhang Y, Liu Q, Liu M . High Low-Density Lipoprotein Cholesterol Levels are Associated with Osteoporosis Among Adults 20-59 Years of Age. Int J Gen Med. 2022; 15:2261-2270. PMC: 8896571. DOI: 10.2147/IJGM.S353531. View

Kim J, Ha J, Jeong C, Lee J, Lim Y, Jo K . Bone mineral density and lipid profiles in older adults: a nationwide cross-sectional study. Osteoporos Int. 2022; 34(1):119-128. DOI: 10.1007/s00198-022-06571-z. View

Schroeder J, Turner S, Buck E . Hip Fractures: Diagnosis and Management. Am Fam Physician. 2022; 106(6):675-683. View

Liu M, Chu Q, Yang C, Wang J, Fu M, Zhang Z . The paradoxical relation between serum uric acid and outcomes of hip fracture in older patients after surgery: A 1-year follow-up study. Surgery. 2022; 172(5):1576-1583. DOI: 10.1016/j.surg.2022.07.008. View

10.

Zeng X, Zhan K, Zhang L, Zeng D, Yu W, Zhang X . The impact of high total cholesterol and high low-density lipoprotein on avascular necrosis of the femoral head in low-energy femoral neck fractures. J Orthop Surg Res. 2017; 12(1):30. PMC: 5316144. DOI: 10.1186/s13018-017-0532-0. View

11.

Kadri A, Binkley N, Daffner S, Anderson P . Fracture in Patients with Normal Bone Mineral Density: An Evaluation of the American Orthopaedic Association's Own the Bone Registry. J Bone Joint Surg Am. 2022; 105(2):128-136. DOI: 10.2106/JBJS.22.00012. View

12.

Asai N, Ohashi W, Sakanashi D, Suematsu H, Kato H, Hagihara M . Combination of Sequential Organ Failure Assessment (SOFA) score and Charlson Comorbidity Index (CCI) could predict the severity and prognosis of candidemia more accurately than the Acute Physiology, Age, Chronic Health Evaluation II (APACHE II) score. BMC Infect Dis. 2021; 21(1):77. PMC: 7811217. DOI: 10.1186/s12879-020-05719-8. View

13.

Noale M, Limongi F, Maggi S . Epidemiology of Cardiovascular Diseases in the Elderly. Adv Exp Med Biol. 2020; 1216:29-38. DOI: 10.1007/978-3-030-33330-0_4. View

14.

Pelton K, Krieder J, Joiner D, Freeman M, Goldstein S, Solomon K . Hypercholesterolemia promotes an osteoporotic phenotype. Am J Pathol. 2012; 181(3):928-36. PMC: 3432436. DOI: 10.1016/j.ajpath.2012.05.034. View

15.

Durstine J, Grandjean P, Davis P, Ferguson M, Alderson N, DuBose K . Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis. Sports Med. 2001; 31(15):1033-62. DOI: 10.2165/00007256-200131150-00002. View

16.

Sato Y, Hosonuma M, Sugawara D, Azetsu Y, Karakawa A, Chatani M . Cholesterol and fat in diet disrupt bone and tooth homeostasis in mice. Biomed Pharmacother. 2022; 156:113940. DOI: 10.1016/j.biopha.2022.113940. View

17.

Barzilay J, Buzkova P, Kuller L, Cauley J, Fink H, Sheets K . The Association of Lipids and Lipoproteins with Hip Fracture Risk: The Cardiovascular Health Study. Am J Med. 2022; 135(9):1101-1108.e1. PMC: 9536862. DOI: 10.1016/j.amjmed.2022.05.024. View

18.

Sung K, Huh J, Ryu S, Lee J, Scorletti E, Byrne C . Low Levels of Low-Density Lipoprotein Cholesterol and Mortality Outcomes in Non-Statin Users. J Clin Med. 2019; 8(10). PMC: 6832139. DOI: 10.3390/jcm8101571. View

19.

Ge B, Lu S, Lei S . The obesity indices mediate the relationships of blood lipids and bone mineral density in Chinese elders. Mol Cell Probes. 2021; 56:101705. DOI: 10.1016/j.mcp.2021.101705. View

20.

Choi H, Lee Y, Rhyu S, Kwon B, Lee J . Mortality and cause of death postoperatively in patients with a hip fracture: a national cohort longitudinal follow-up study. Bone Joint J. 2018; 100-B(4):436-442. DOI: 10.1302/0301-620X.100B4.BJJ-2017-0993.R2. View