Circumferential Stenosis of the Second Part of the Duodenum Caused by Eosinophilic Gastroenteritis

Overview

Journal Intern Med

Specialty General Medicine

Date 2023 Sep 4

PMID 37661445

Authors

Hajime Honjo

Kosuke Minaga

Akane Hara

Ryutaro Takada

Yasuo Otsuka

Yasuhiro Masuta

Sho Masaki

Shigenaga Matsui

Masatoshi Kudo

Tomohiro Watanabe

Affiliations

Soon will be listed here.

Abstract

Isolated eosinophilic gastroenteritis (EGE) of the second part of the duodenum is rare. We herein report a case of EGE limited to the second part of the duodenum that caused circumferential stenosis due to massive wall thickening. A boring biopsy was useful to verify the accumulation of eosinophils. Induction of remission by prednisolone was accompanied by a marked reduction in the mRNA expression of interleukin-6, C-C motif chemokine ligand 17 (CCL17), and CCL26 without any reduction in prototypical EGE-associated T helper type 2 cytokines (IL-5, IL-13). Thus, the enhanced expression of IL-6, CCL17, and CCL26 might be involved in the development of EGE in this case.

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