Subjective Versus Objective Sleep in Men with Klinefelter Syndrome

Overview

Journal Orphanet J Rare Dis

Publisher Biomed Central

Specialty General Medicine

Date 2023 Sep 1

PMID 37658437

Authors

K W Fjermestad

R R Finnbakk

A-K Solbakk

C H Gravholt

R J Huster

Affiliations

Soon will be listed here.

Abstract

Objectives: To investigate sleep among men with Klinefelter syndrome (KS).

Method: We compared the sleep domains latency, disturbance, and efficiency in 30 men with KS (M age = 36.7 years, SD = 10.6) to 21 age-matched non-KS controls (M age = 36.8 years, SD = 14.4). Actigraphs were used to objectively measure sleep across 7 days and nights. Participants also completed a sleep diary over the same period, and the Pittsburgh Sleep Quality Index (PSQI).

Results: The mean correlation between the objective and subjective sleep measures was lower for the KS sample (M r = .15) than for controls (M r = .34). Sleep disturbance was significantly larger in the KS sample, as measured by actigraphy (p = .022, d = 0.71) and the PSQI (p = .037, d = 0.61). In regression models predicting sleep domains from KS status, age, educational level, vocational status, IQ, and mental health, KS status was not a significant predictor. Higher age was associated with more actigraphy-measured sleep disturbance. Higher educational level and being employed were associated with better sleep efficiency.

Conclusions: Sleep disturbance may be a particular problem for men with KS and should be measured with complimentary methods.

Citing Articles

Evaluation of sleep disorders in children and adolescents affected by Klinefelter syndrome.

Paparella R, Panvino F, Gambuti L, Cerrito A, Pallante A, Micangeli G Eur J Pediatr. 2025; 184(2):129.

PMID: 39798041 PMC: 11724788. DOI: 10.1007/s00431-024-05944-2.

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