Preeclampsia Complicated with Hypofibrinogenemia: 2 Case Reports and Review of the Literature

Overview

Journal BMC Pregnancy Childbirth

Publisher Biomed Central

Specialty Gynecology & Obstetrics

Date 2023 Sep 1

PMID 37658306

Authors

Shiguang Li

Yanhui Jin

Yanmin Gong

Xia Luo

Affiliations

Soon will be listed here.

Abstract

Background: Preeclampsia complicated with hypofibrinogenemia is a rare disorder. We report two cases of severe preeclampsia complicated with hypofibrinogenemia followed by postpartum haemorrhage (PPH).

Case: Two women diagnosed as preeclampsia and hypofibrinogenemia developed severe PPH after undergoing Cesarean sections. Besides supplement with fibrinogen concentrate and supportive treatment, the second patient got administration of heparin after delivery and bleeding was stopped. The haemorrhage in case 1 didn't disappear until an hysterectomy. The two patients both recovered and were discharged soon.

Conclusions: Severe preeclampsia patients with hypofibrinogenemia could suffer PPH. It's necessary to detect and master coagulation function. Heparin could be considered to balance hypercoagulation and hypocoagulation to avoid catastrophic haemorrhage and hysterectomy.

Citing Articles

Placental Origins of Preeclampsia: Insights from Multi-Omic Studies.

Cao C, Saxena R, Gray K Int J Mol Sci. 2024; 25(17).

PMID: 39273292 PMC: 11395466. DOI: 10.3390/ijms25179343.

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