» Articles » PMID: 37657964

Effects of COVID-19 on Cognition and Brain Health

Overview
Journal Trends Cogn Sci
Date 2023 Sep 1
PMID 37657964
Authors
Affiliations
Soon will be listed here.
Abstract

COVID-19 is associated with a range of neurological, cognitive, and mental health symptoms both acutely and chronically that can persist for many months after infection in people with long-COVID syndrome. Investigations of cognitive function and neuroimaging have begun to elucidate the nature of some of these symptoms. They reveal that, although cognitive deficits may be related to brain imaging abnormalities in some people, symptoms can also occur in the absence of objective cognitive deficits or neuroimaging changes. Furthermore, cognitive impairment may be detected even in asymptomatic individuals. We consider the evidence regarding symptoms, cognitive deficits, and neuroimaging, as well as their possible underlying mechanisms.

Citing Articles

Choroid plexus volume is enlarged in long COVID and associated with cognitive and brain changes.

Diez-Cirarda M, Yus-Fuertes M, Delgado-Alonso C, Gil-Martinez L, Jimenez-Garcia C, Gil-Moreno M Mol Psychiatry. 2025; .

PMID: 39815057 DOI: 10.1038/s41380-024-02886-x.


The population based cognitive testing in subjects with SARS-CoV-2 (POPCOV2) study: longitudinal investigation of remote cognitive and fatigue screening in PCR-positive cases and negative controls.

von Etzdorf A, Harzen M, Heinrichs H, Seifert H, Groiss S, Balloff C Front Hum Neurosci. 2024; 18:1468204.

PMID: 39677403 PMC: 11638161. DOI: 10.3389/fnhum.2024.1468204.


Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis.

Shan D, Wang C, Crawford T, Holland C BMC Geriatr. 2024; 24(1):940.

PMID: 39674870 PMC: 11646349. DOI: 10.1186/s12877-024-05538-5.


Long COVID: A Comprehensive Overview of the Signs and Symptoms across Multiple Organ Systems.

Merhavy Z, Junor T, Gonzalez A, De Filippis S, Oveisitork S, Rivera E Korean J Fam Med. 2024; 45(6):305-316.

PMID: 39600184 PMC: 11605154. DOI: 10.4082/kjfm.24.0085.


Characterization of Change in Cognition Before and After COVID-19 Infection in Essential Workers at Midlife.

Sekendiz Z, Morozova O, Carr M, Fontana A, Mehta N, Ali A Am J Med Open. 2024; 12:100076.

PMID: 39498311 PMC: 11533481. DOI: 10.1016/j.ajmo.2024.100076.


References
1.
Danesh V, Arroliga A, Bourgeois J, Boehm L, McNeal M, Widmer A . Symptom Clusters Seen in Adult COVID-19 Recovery Clinic Care Seekers. J Gen Intern Med. 2022; 38(2):442-449. PMC: 9663188. DOI: 10.1007/s11606-022-07908-4. View

2.
Canas L, Molteni E, Deng J, Sudre C, Murray B, Kerfoot E . Profiling post-COVID-19 condition across different variants of SARS-CoV-2: a prospective longitudinal study in unvaccinated wild-type, unvaccinated alpha-variant, and vaccinated delta-variant populations. Lancet Digit Health. 2023; 5(7):e421-e434. PMC: 10187990. DOI: 10.1016/S2589-7500(23)00056-0. View

3.
Benedetti F, Palladini M, Paolini M, Melloni E, Vai B, De Lorenzo R . Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging study. Brain Behav Immun Health. 2021; 18:100387. PMC: 8562046. DOI: 10.1016/j.bbih.2021.100387. View

4.
Cysique L, Jakabek D, Bracken S, Allen-Davidian Y, Heng B, Chow S . The kynurenine pathway relates to post-acute COVID-19 objective cognitive impairment and PASC. Ann Clin Transl Neurol. 2023; 10(8):1338-1352. PMC: 10424655. DOI: 10.1002/acn3.51825. View

5.
Frontera J, Boutajangout A, Masurkar A, Betensky R, Ge Y, Vedvyas A . Comparison of serum neurodegenerative biomarkers among hospitalized COVID-19 patients versus non-COVID subjects with normal cognition, mild cognitive impairment, or Alzheimer's dementia. Alzheimers Dement. 2022; 18(5):899-910. PMC: 9011610. DOI: 10.1002/alz.12556. View