Discovery of Cisplatin-binding Proteins by Competitive Cysteinome Profiling

Overview

Journal RSC Chem Biol

Publisher Royal Society of Chemistry

Specialty Biology

Date 2023 Sep 1

PMID 37654507

Authors

Xianghe Wang

Yihai Zhang

Chu Wang

Affiliations

Soon will be listed here.

Abstract

Cisplatin is a widely used cancer metallodrug that induces cytotoxicity by targeting DNA and chelating cysteines in proteins. Here we applied a competitive activity-based protein profiling strategy to identify cisplatin-binding cysteines in cancer proteomes. A novel cisplatin target, MetAP1, was identified and functionally validated to contribute to cisplatin's cytotoxicity.

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